Publication Tracker \u2014 ASH
Live timeline of 10030 PMID-verified articles ASH tracks. Filter by category to explore the literature growth toward our 10,000-paper coverage goal.
This page is the public face of ASH's literature-tracking pipeline. Every entry here is parsed from PubMed metadata directly, cross-checked against the article's real PMID, and committed into the open-source registry behind this site. Hand-curated registries are tracked separately at PMID Audit Status.
The corpus grows continuously as new PubMed-indexed hirudotherapy and leech-derived-compound papers are published. The 10,000-article goal is the coverage threshold needed to consider ASH's literature surveillance comprehensive across all leech-related biomedical sub-fields.
10030
Total tracked articles
PMID-verified, auto-imported from PubMed
2007
Added in last 12 months
Rolling window ending 2026-05-27
100%
Progress toward 10,000-paper goal
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Showing 959 articles in Salivary Pharmacology. Clear filter
Timeline by publication year
2026
42 articlesCurrent yearAndexanet alfa for the reversal of anticoagulation: Dutch practice data
Krommenhoek JF et al. · Research and practice in thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Autoimmune heparin-induced thrombocytopenia following cardiac surgery.
St Bernard R et al. · BMJ case reports
Added to ASH registry: 2026-05-28
Circadian Rhythm and Efficacy of Argatroban in Ischemic Stroke with Alteplase: A Post Hoc Analysis of the ARAIS Trial
Chen et al. · CNS drugs
Added to ASH registry: 2026-05-28
Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review.
Rehman A et al. · World journal of methodology
Added to ASH registry: 2026-05-28
Effects of cardiopulmonary bypass on in vitro proliferation of human pancreatic cancer cells and plasma growth factor levels
Katagiri et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-28
Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor
Rafaelian A et al. · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Added to ASH registry: 2026-05-28
Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy
Cheng R et al. · Blood
Added to ASH registry: 2026-05-28
Excessive Apixaban Concentrations in a Bleeding Patient Treated With Pharmacological Reversal and Extracorporal Removal-A Case Report
Kraus RF et al. · Pharmacology research & perspectives
Added to ASH registry: 2026-05-28
Fondaparinux versus argatroban for the management of suspected or confirmed heparin-induced thrombocytopenia: a propensity score-matched cohort study.
Alfehaid L et al. · Frontiers in medicine
Added to ASH registry: 2026-05-28
Nafamostat Mesilate as an Anticoagulation Strategy for Heparin-Induced Thrombocytopenia: A Case Report.
Mei S et al. · Journal of blood medicine
Added to ASH registry: 2026-05-28
Notch signaling in leech neurogenesis: expression patterns and functional insights in the Glossiphoniid leech.
Jeong et al. · Animal cells and systems
Added to ASH registry: 2026-05-28
Review of the Current Issues Surrounding Monitoring of the Direct Thrombin Inhibitor Argatroban in the Laboratory.
Guy S et al. · International journal of laboratory hematology
Added to ASH registry: 2026-05-28
Salivary Nitrate Maintains Mucosal Homeostasis via the Sialin-Neuropeptide Axis
Li et al. · Journal of dental research
Added to ASH registry: 2026-05-28
Sibakazin: a novel black fly derived non-classical kazal protease inhibitor, targeting antiplatelet (P2Y12/GPVI) pathways without perturbing coagulation
Li Z et al. · Insect biochemistry and molecular biology
Added to ASH registry: 2026-05-28
The unique biogenesis pathway of extracellular vesicles in Hirudo nipponia salivary gland cells
Zhu et al. · Tissue & cell
Added to ASH registry: 2026-05-28
Thrombin generation and the pharmacodynamics of parenteral anticoagulants.
Shaw JR et al. · Pharmacological reviews
Added to ASH registry: 2026-05-28
Use of argatroban as anticoagulation for cardiopulmonary bypass during heart transplantation: A case report.
Faggioli M et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-28
VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.
Yamaguchi A et al. · Blood vessels, thrombosis & hemostasis
Added to ASH registry: 2026-05-28
Anticoagulant peptide LR from Whitmania pigra ameliorates cerebral ischemia-reperfusion injury
Liu R et al. · Brain research
Added to ASH registry: 2026-05-27
Anticoagulant peptide LR from Whitmania pigra ameliorates cerebral ischemia-reperfusion injury
Liu R et al. · Brain Research
Added to ASH registry: 2026-05-27
Anticoagulation associated intracerebral haemorrhage trends, treatment and outcomes in a metropolitan cohort: analysed by availability of specific versus non-specific reversal agents
El-Masri S et al. · BMJ neurology open
Added to ASH registry: 2026-05-27
Anticoagulation Stewardship Program in the DOAC Era
Ng JX et al. · Journal of clinical medicine
Added to ASH registry: 2026-05-27
Construction of Corynebacterium glutamicum for efficient secretion and production of recombinant proteins using the technology of ARTP mutagenesis and fluorescen activated droplet microfluidic screening
Liu X et al. · Bioresource technology
Added to ASH registry: 2026-05-27
Dabigatran-induced Gastrointestinal Bleed Treated by 4-factor Prothrombin Complex Concentrate in a Tertiary Care Hospital in Sikkim
Dhakal M et al. · The Journal of the Association of Physicians of India
Added to ASH registry: 2026-05-27
Duplication of the Antistasin-Like Structure Resulted in a New Anticoagulant Protein in the Medicinal Leech
Brovina KA et al. · Biomolecules
Added to ASH registry: 2026-05-27
Elucidating the neuroinflammatory modulatory mechanisms of Maixuekang capsule via network pharmacology and proteomics
Han et al. · Developmental neurobiology
Added to ASH registry: 2026-05-27
Elucidating the Neuroinflammatory Modulatory Mechanisms of Maixuekang Capsule via Network Pharmacology in Cerebral Ischemia/Reperfusion Injury Rats
Han H et al. · Developmental Neurobiology
Added to ASH registry: 2026-05-27
ERGA-BGE reference genome of a once neglected freshwater haematophagous European medicinal leech
Manzano-Marin A et al. · Open research Europe
Added to ASH registry: 2026-05-27
Genetically Encoded Multivalent Elastin-Like Polypeptide-Haemadin Fusion Proteins for Prolonged Antithrombotic Protection
Yang H et al. · Biomacromolecules
Added to ASH registry: 2026-05-27
Hirudin ameliorates kidney injury in DKD mice by decreasing SOD2 β-hydroxybutyrylation mediated ROS level and NLRP3 inflammasome formation
Li Y et al. · FASEB journal
Added to ASH registry: 2026-05-27
Hirudin suppresses ovarian cancer cell proliferation and glycolysis through inhibiting the NF-B/HK3 axis
Guo Y et al. · Gene
Added to ASH registry: 2026-05-27
Identification and characterization of WpDestabilase, a novel destabilase from the salivary glands of Whitmania pigra
Huang B et al. · Protein expression and purification
Added to ASH registry: 2026-05-27
Molecular Insights into Leech-Derived Bioactive Compounds: Biochemical Mechanisms and Therapeutic Potential
Raghavi S et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Recombinant Fusion Protein Composed of Hirudin and Annexin A5 Shows Anti-Coagulant Activity In Vitro
Dong H et al. · Applied biochemistry and biotechnology
Added to ASH registry: 2026-05-27
Role of argatroban infusion in controlling clot formation in post-cardiac surgical extracorporeal membrane oxygenation in pediatrics: A case series of three patients
Samhan LM et al. · Perfusion
Added to ASH registry: 2026-05-27
Safety and Outcomes of Dabigatran Reversal With Idarucizumab Before IV Thrombolysis in Patients With Acute Ischemic Stroke
Sflund M et al. · Neurology
Added to ASH registry: 2026-05-27
The great diversity: monomeric and oligomeric hirudins, hirudin-like factors and decorsins in the Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis
Kalatehjari P et al. · Parasitology research
Added to ASH registry: 2026-05-27
Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations
Li W et al. · Frontiers in endocrinology
Added to ASH registry: 2026-05-27
Updates on Use and Monitoring of Direct Thrombin Inhibitors
Navaei A et al. · Clinics in laboratory medicine
Added to ASH registry: 2026-05-27
Molecular Insights into Leech-Derived Bioactive Compounds: Biochemical Mechanisms and Therapeutic Potential
Raghavi S, Deva Darshini B, Saravanan KM, Anbarasu K · International journal of molecular sciences
Added to ASH registry: 2026-05-26
Effects of hirudotherapy on liver functions, lipid profile, and insulin sensitivity in rats with metabolic syndrome
Bilden A et al. · BMC complementary medicine and therapies
Added to ASH registry: 2026-03-18
Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial
Abtahi-Forooshani M et al. · Health science reports
Added to ASH registry: 2026-03-18
2025
75 articlesA UK-wide analysis of 2265 patients receiving a reversal agent for direct oral anticoagulant-associated bleeding.
? et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Andexanet Alfa in Emergency Cranial Neurosurgical Procedures: A Bicentric Analysis of Efficacy and Safety
Hounchonou HF et al. · Neurocritical care
Added to ASH registry: 2026-05-28
Andexanet Alfa in Urgent Cardiac Surgery: A Case Report of Edoxaban Reversal for Acute Hemopericardium.
Al Mawed M et al. · The American journal of case reports
Added to ASH registry: 2026-05-28
Anticoagulation and hemostasis in the extracorporeal membrane oxygenation patient.
Saura O et al. · Current opinion in anaesthesiology
Added to ASH registry: 2026-05-28
Bivalirudin for anticoagulation in elderly acute coronary syndrome: Effects on myocardial microcirculation and adverse events.
Cheng CY et al. · World journal of clinical cases
Added to ASH registry: 2026-05-28
Correction of the effect of direct oral and parenteral anticoagulants in hemorrhagic stroke.
Baranich AI et al. · Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
Added to ASH registry: 2026-05-28
Effects of bivalirudin on instant blood-mediated inflammatory reaction after intraportal islet transplantation
Liang et al. · Cell transplantation
Added to ASH registry: 2026-05-28
Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management.
Rivera Jiménez et al. · Medicina (Kaunas, Lithuania)
Added to ASH registry: 2026-05-28
Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway
Lan F et al. · Acta cirurgica brasileira
Added to ASH registry: 2026-05-28
Hirudin promotes peripheral nerve repair and alleviates pain by regulating the EGFR-PI3K/AKT/mTOR pathway
Wu L et al. · Archives of biochemistry and biophysics
Added to ASH registry: 2026-05-28
Hirudin-Like Noninvasive Polyurethane Solid Anticoagulant Fabricated by One-Pot In Situ Solution Polymerization and Phase Conversion Methods
Qu Y et al. · ACS applied materials & interfaces
Added to ASH registry: 2026-05-28
Intravenous thrombolysis for patients with acute ischemic stroke while receiving a direct oral anticoagulant: A systematic review and meta-analysis.
Roberts MZ et al. · Pharmacotherapy
Added to ASH registry: 2026-05-28
Investigating the Therapeutic Potential of Crude Leech Saliva Based on Its Anticancer, Antioxidant, and Anti-Inflammatory Effects
Bilden et al. · Current issues in molecular biology
Added to ASH registry: 2026-05-28
Multiterritory Brain Infarcts, Anticoagulation, and Recurrence After Cryptogenic Stroke: A Subgroup Analysis of the ARCADIA Trial
Gologorsky et al. · Stroke
Added to ASH registry: 2026-05-28
Population Genetics of the Asian Buffalo Leech (Hirudinaria manillensis) in Southern China Based on Mitochondrial Protein-Coding Genes
Lin et al. · Biology
Added to ASH registry: 2026-05-28
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants.
Chen G et al. · Nature biomedical engineering
Added to ASH registry: 2026-05-28
Rapid Cultivation of Acanthamoeba spp. Isolated from Environmental Samples Using Nanocomposite and Leech Saliva on Non-Nutrient Agar
Bilden et al. · Acta parasitologica
Added to ASH registry: 2026-05-28
Rebalancing agents in hemophilia: knowns, unknowns, and uncertainties.
Van Thillo et al. · Haematologica
Added to ASH registry: 2026-05-28
Recent progress on formulations of hirudin
Bao Z et al. · Pharmaceutical science advances
Added to ASH registry: 2026-05-28
Retraction: Hirudin ameliorates immunoglobulin a nephropathy by inhibition of fibrosis and inflammatory response
Anonymous · Renal failure
Added to ASH registry: 2026-05-28
SYNONYMIZATION OF PLACOBDELLA PICTA (VERRILL, 1872) (HIRUDINEA: GLOSSIPHONIIDAE) WITH DESCRIPTIONS OF TWO NEW SPECIES REVEALED BY MOLECULAR SPECIES DELIMITATION.
Phillips AJ et al. · The Journal of parasitology
Added to ASH registry: 2026-05-28
Targeting thrombin with hirudin alleviates paraquat-induced pulmonary fibrosis via the PAR-1-mediated TGF-β1 pathway.
Hu X et al. · Histology and histopathology
Added to ASH registry: 2026-05-28
Time to hemostatic agent administration increases mortality in veterans with factor Xa inhibitor-related intracranial hemorrhage
Markovic N et al. · The American journal of emergency medicine
Added to ASH registry: 2026-05-28
Tracheal Hirudiniasis Induced by Ingestion of Unboiled Mountain Spring Water
Ni et al. · The American journal of tropical medicine and hygiene
Added to ASH registry: 2026-05-28
Trends and variation in the use of andexanet alfa for the reversal of direct oral anticoagulants in NHS trusts in England
Fisher L et al. · British journal of clinical pharmacology
Added to ASH registry: 2026-05-28
Twenty years of the four-factor prothrombin complex concentrate Octaplex/Balfaxar: A narrative review
Karkouti K et al. · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
Added to ASH registry: 2026-05-28
Vascular endothelial cell-targeted mRNA delivery via synthetic lipid nanoparticles for venous thrombosis prevention.
Guo et al. · Journal of controlled release : official journal of the Controlled Release Society
Added to ASH registry: 2026-05-28
Volume and Location Analysis of Intracerebral Hemorrhage for the Appropriate Use of Andexanet Alfa
Umemura T et al. · Neurologia medico-chirurgica
Added to ASH registry: 2026-05-28
2025 Guidelines for direct oral anticoagulants: a practical guidance on the prescription, laboratory testing, peri-operative and bleeding management
Tran HA et al. · Internal medicine journal
Added to ASH registry: 2026-05-27
A biomimetic macrophage-membrane-fused liposomal system loaded with GVs-HV recombinant plasmid for targeted anti-atherosclerosis therapy
Zhang Y et al. · Pharmaceutics
Added to ASH registry: 2026-05-27
A novel integrated strategy for discovering absorbable anticoagulant bioactive peptides: a case study on leech protein hydrolysates
Fang KX et al. · Molecules
Added to ASH registry: 2026-05-27
Anticoagulants: from chance discovery to structure-based design
Chan N et al. · Pharmacological reviews
Added to ASH registry: 2026-05-27
Application of promoting blood circulation and resolving blood stasis in intracerebral hemorrhage: a traditional method gradually moving toward modern stroke care
Dingshan Z et al. · Journal of traditional Chinese medicine
Added to ASH registry: 2026-05-27
Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae)
Khan MS et al. · BMC genomics
Added to ASH registry: 2026-05-27
Comparative genomics suggests extensive antithrombotic gene expansion in Haemadipsa yanyuanensis
Lin Y et al. · BMC genomics
Added to ASH registry: 2026-05-27
Comparative study of hirustasin superfamily gene expression in two medicinal leeches
Sun et al. · Genes
Added to ASH registry: 2026-05-27
Cost-effectiveness of dabigatran for thromboembolic events prevention in atrial fibrillation patients in Chile
Abbot T et al. · Cost effectiveness and resource allocation : C/E
Added to ASH registry: 2026-05-27
Dabigatran-idarucizumab pharmacokinetics-pharmacodynamics in sheep undergoing cardiopulmonary bypass
Eaton MP et al. · Perfusion
Added to ASH registry: 2026-05-27
Distribution and blood penetration of hirudin in various organs and tissues of rabbits with carotid artery injury
Feng Y et al. · Journal of analytical methods in chemistry
Added to ASH registry: 2026-05-27
Emergency Reversal of Antithrombotics in Intracerebral Hemorrhage: An Update
Li M et al. · Current neurology and neuroscience reports
Added to ASH registry: 2026-05-27
Engineering ultrapotent trivalent anticoagulants through hybridisation of salivary peptides from multiple haematophagous organisms
Maxwell JWC et al. · Chemical science
Added to ASH registry: 2026-05-27
Expression of Recombinant Hirudin in Bacteria and Yeast: A Comparative Approach
Wang Z et al. · Methods Protoc
Added to ASH registry: 2026-05-27
Genetic variation and gene expression of the antimicrobial peptide macins in Asian Buffalo Leech
Yu Y et al. · Biology
Added to ASH registry: 2026-05-27
Hirudin promotes cerebral angiogenesis and exerts neuroprotective effects in MCAO/R rats by activating the Wnt/-catenin pathway
He L et al. · J Stroke Cerebrovasc Dis
Added to ASH registry: 2026-05-27
Hirudin-based treatment of diabetes-induced erectile dysfunction through inhibition of the HIF-1α to regulate RhoA/ROCK signaling pathway
Sun L et al. · American journal of men's health
Added to ASH registry: 2026-05-27
Hirudins and fenestrins of the African medicinal leech Asiaticobdella fenestrata
Schulz L et al. · Parasitology research
Added to ASH registry: 2026-05-27
Idarucizumab more effectively reverses the anticoagulant effects of dabigatran acylglucuronide than dabigatran
Kim JM et al. · Scientific reports
Added to ASH registry: 2026-05-27
Identification and Screening of Novel Antimicrobial Peptides from Medicinal Leech via Heterologous Expression in E. coli
Serebrennikova M et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Intravenous Dabigatran for Anticoagulation during Cardiopulmonary Bypass in a Sheep Model
Nadtochiy SM et al. · Anesthesiology
Added to ASH registry: 2026-05-27
Investigating the therapeutic potential of medical leech and leech saliva extract in flap survival: an experimental study using rats
Ünal K et al. · Journal of complementary & integrative medicine
Added to ASH registry: 2026-05-27
Latin America Multidisciplinary Consensus Panel on Management of Severe Bleeding in the Anticoagulated Patient
Pontes-Neto OM et al. · The Journal of emergency medicine
Added to ASH registry: 2026-05-27
Leech Extract Enhances the Pro-Angiogenic Effects of Endothelial Cell-Derived Exosomes in a Mouse Model of Ischemic Stroke
Cao Y et al. · Current issues in molecular biology
Added to ASH registry: 2026-05-27
Management of emergencies in direct oral anticoagulant-treated patients: practice pearls
Ztroch I et al. · Orvosi hetilap
Added to ASH registry: 2026-05-27
Molecular cloning and functional analysis of a destabilase from Hirudinaria manillensis
Gao T et al. · Protein expression and purification
Added to ASH registry: 2026-05-27
Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech
Tolksdorf C et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Morphological and anatomical deformities of Hirudo verbana after feeding: light and electron microscopic analysis
Ülger Ö et al. · Microscopy and microanalysis
Added to ASH registry: 2026-05-27
Multi-target anticoagulant regulation by peptides from medicinal leeches: a unique natural strategy
Shi et al. · Pharmaceutical research
Added to ASH registry: 2026-05-27
Neuroprotective effects of hirudin against cerebral ischemia-reperfusion injury via inhibition of CCL2-mediated ferroptosis and inflammatory pathways
Liao J et al. · Brain Res Bull
Added to ASH registry: 2026-05-27
Optimization of conditions related to Chrono-log platelet aggregation in feline whole blood
Huang W et al. · Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
Added to ASH registry: 2026-05-27
Outcomes and current state of deep inferior epigastric perforator flap surgery in Peru and Mexico
Ziegler Rodriguez OR et al. · Plastic and reconstructive surgery. Global open
Added to ASH registry: 2026-05-27
Platelet derived prothrombotic microparticles and adverse events in patients supported with Impella 5.5
D'Ettore N et al. · The International journal of artificial organs
Added to ASH registry: 2026-05-27
Production and functional characteristics of a novel hirudin variant with better anticoagulant activities than bivalirudin
Ge P et al. · Journal of enzyme inhibition and medicinal chemistry
Added to ASH registry: 2026-05-27
Production, Purification, and Characterization of a Novel Cysteine-Rich Anticoagulant from the Medicinal Leech and the Functional Role of Its Disulfide Bonds
Manuvera VA et al. · Biomolecules
Added to ASH registry: 2026-05-27
Recombinant hirudin prevents against nonalcoholic fatty liver disease by modulating PAR1/JAK2/STAT5/STAT3/CD36 pathway
Xiaoyu YU et al. · Biochimica et biophysica acta. Molecular and cell biology of lipids
Added to ASH registry: 2026-05-27
Sonorheometry parameters during dabigatran reversal with idarucizumab for major bleeding
Teissandier D et al. · The Journal of pharmacology and experimental therapeutics
Added to ASH registry: 2026-05-27
Species delimitation recovers undescribed Erpobdellidae (Annelida: Hirudinea) from USA and Turkiye
Saglam N et al. · Zootaxa
Added to ASH registry: 2026-05-27
Supramolecular Prodrug Hydrogel for One-Week Protection Against Thrombosis
Zhang W et al. · Small
Added to ASH registry: 2026-05-27
The clinical efficacy of herbal medicines containing leeches in the treatment of coronary heart disease: a systematic review and meta-analysis
Ziyuan Z et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Thrombosis and Coagulopathy
Savi M et al. · Neurosurgery clinics of North America
Added to ASH registry: 2026-05-27
Time to Reconsidering the Potential Role of Leech Salivary Proteins in Medicine: Type-II Kounis Syndrome Triggered by Leech Bite
Tas B et al. · Pakistan journal of medical sciences
Added to ASH registry: 2026-05-27
Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway
Wu S et al. · CNS neuroscience & therapeutics
Added to ASH registry: 2026-05-27
Traditional uses, chemical constituents, pharmacological activities and toxicology of Chinese medicinal leech (Shuizhi): A comprehensive review
Liu J et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-27
Unveiling salivary gland-specific gene expression of Piezo1 and Neuroendocrine in the leech Helobdella austinensis
Pyo IH et al. · Developmental and comparative immunology
Added to ASH registry: 2026-05-27
Discovery of a Thrombin-Targeting Anticoagulant Peptide From Whitmania pigra via a 'Computation-Guided Experimentation' Strategy
Hua YT et al. · Journal of peptide science : an official publication of the European Peptide Society
Added to ASH registry: 2026-05-26
Novel drug delivery systems for hirudin-based product development and clinical applications
Mo L et al. · International journal of biological macromolecules
Added to ASH registry: 2026-03-18
2024
62 articles[Overdosing of direct oral anticoagulants].
Neumann MA et al. · Medizinische Klinik, Intensivmedizin und Notfallmedizin
Added to ASH registry: 2026-05-28
Allosteric Modulation of Thrombin by Thrombomodulin: Insights from Logistic Regression and Statistical Analysis of Molecular Dynamics Simulations.
Wu D et al. · ACS omega
Added to ASH registry: 2026-05-28
Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion.
Groba Marco MDV et al. · Clinical transplantation
Added to ASH registry: 2026-05-28
Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet-α, protamine).
Bekka E et al. · British journal of clinical pharmacology
Added to ASH registry: 2026-05-28
Beyond Anticoagulation: A Comprehensive Review of Non-Vitamin K Oral Anticoagulants (NOACs) in Inflammation and Protease-Activated Receptor Signaling.
Jannati S et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-28
Challenges to Laboratory Monitoring of Direct Oral Anticoagulants.
Qiao J et al. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Added to ASH registry: 2026-05-28
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis.
Yamakawa et al. · International journal of hematology
Added to ASH registry: 2026-05-28
Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases
Pineda-Reyes R et al. · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Added to ASH registry: 2026-05-28
Direct oral anticoagulants in trauma patients.
Schöchl H et al. · Current opinion in anaesthesiology
Added to ASH registry: 2026-05-28
Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy
Tsikis et al. · American journal of physiology. Lung cellular and molecular physiology
Added to ASH registry: 2026-05-28
Diterpenes Isolated from Three DifferentSpecies and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells.
Gáborová M et al. · ACS omega
Added to ASH registry: 2026-05-28
Efficacy and safety of antithrombotic therapy for preventing and treating pediatric thromboembolic disease: a systematic review.
Gao H et al. · Scientific reports
Added to ASH registry: 2026-05-28
Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice
Mei T et al. · Biomaterials
Added to ASH registry: 2026-05-28
Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update.
Frol et al. · Frontiers in neurology
Added to ASH registry: 2026-05-28
Immune-stealth VP28-conjugated heparin nanoparticles for enhanced and reversible anticoagulation.
Hussein et al. · Nanotechnology
Added to ASH registry: 2026-05-28
Is bivalirudin ready for a comeback? Pros and cons.
Stone GW et al. · EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Added to ASH registry: 2026-05-28
Letter to the editor: 1-year clinical outcomes of bivalirudin vs. unfractionated heparin in patients with type 2 diabetes undergoing elective percutaneous coronary intervention.
Rajab F et al. · European heart journal. Cardiovascular pharmacotherapy
Added to ASH registry: 2026-05-28
Life cycle and development of the marine leech Branchellion lobata (Hirudinea: Piscicolidae), from round stingrays, Urobatis halleri, from southern California
Lizarraga et al. · Scientific reports
Added to ASH registry: 2026-05-28
Lymphatic Uptake of a Highly Lipophilic Protease Inhibitor Prodrug from a Lipid-Based Formulation is Limited by Instability in the Intestine.
Xie Y et al. · Journal of pharmaceutical sciences
Added to ASH registry: 2026-05-28
Met343Val mutation disrupts the shuttling of Trp380 leading to a low-activity conformer of activated protein C and causes thrombosis.
Zhou et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Meta-Analysis Comparing Bivalirudin Versus. Unfractionated Heparin in Adult Patients With Extracorporeal Membrane Oxygenation
Kido et al. · Journal of pharmacy practice
Added to ASH registry: 2026-05-28
Real-world experience of direct oral anticoagulant use in a single pediatric center.
Valenti GG et al. · Pediatric blood & cancer
Added to ASH registry: 2026-05-28
Reversal of dabigatran and apixaban-induced coagulopathy using idarucizumab, fibrinogen, and prothrombin complex concentrate: A case report.
Morando E et al. · Heliyon
Added to ASH registry: 2026-05-28
Targeting tissue factor pathway inhibitor with concizumab to improve hemostasis in patients with Glanzmann thrombasthenia: an in vitro study.
Dubut et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection
Mota et al. · Gene therapy
Added to ASH registry: 2026-05-28
Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants - A Growing Dilemma Also in India.
Meinel TR et al. · Annals of Indian Academy of Neurology
Added to ASH registry: 2026-05-28
Treatment of Cutaneous Leishmaniasis lesion caused by Leishmania major Using Leech Therapy in BALB/c Mice.
Shirani-Bidabadi · Journal of vector borne diseases
Added to ASH registry: 2026-05-28
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.
Mahoney MW et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
A Bioinspired and Cost-Effective Device for Minimally Invasive Blood Sampling
Zoratto N et al. · Advanced science
Added to ASH registry: 2026-05-27
Biomimetic nanoparticles co-deliver hirudin and lumbrukinase to ameliorate thrombus and inflammation for atherosclerosis therapy
Cheng M et al. · Asian journal of pharmaceutical sciences
Added to ASH registry: 2026-05-27
Characterization of a Fatty Acid Amide Hydrolase (FAAH) in Hirudo Verbana
Kabeiseman E et al. · Neurochemical research
Added to ASH registry: 2026-05-27
Chromosome-level genome assembly of the cave leech Sinospelaeobdella cavatuses (Hirudinea: Haemadipsidae)
Yao B et al. · Scientific data
Added to ASH registry: 2026-05-27
Combined drug anti-deep vein thrombosis therapy based on platelet membrane biomimetic targeting nanotechnology
Xiao H et al. · Biomaterials
Added to ASH registry: 2026-05-27
Comparative genomics of two Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis
Zhao et al. · International journal of biological macromolecules
Added to ASH registry: 2026-05-27
Comparison of Outcomes in Patients Requiring Mechanical Circulatory Support Who Received Cangrelor in Addition to Anticoagulation Versus Anticoagulation Alone
Martin TC et al. · Journal of cardiothoracic and vascular anesthesia
Added to ASH registry: 2026-05-27
Efficacy and potential mechanism of atherosclerosis prevention by the active components of leech based on network pharmacology
Lv Q et al. · Heliyon
Added to ASH registry: 2026-05-27
Evaluation of hemostatic, anti-inflammatory, wound healing, skin irritation and acute toxicity of leech (Hirudo nipponia) extract
Li et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-27
Gut microbiota participates and remodels host metabolism: from treating patients to treating their gut flora
Han S et al. · World journal of gastroenterology
Added to ASH registry: 2026-05-27
Heparin-induced DRESS syndrome in a paediatric patient and successful anaesthetic management in cardiovascular bypass surgery: case report
Pea-Blanco L et al. · Journal of cardiothoracic surgery
Added to ASH registry: 2026-05-27
Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis
Zhang J et al. · Biomedicine & pharmacotherapy
Added to ASH registry: 2026-05-27
Identification and functional characterization of multiple haemadins and an oligomeric decorsin in the Asian land leech Haemadipsa interrupta
Müller C et al. · Parasitol Res
Added to ASH registry: 2026-05-27
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway
Zhang Y et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-27
New anticoagulant protein from medicinal leech
Manuvera VA et al. · Biochemical and biophysical research communications
Added to ASH registry: 2026-05-27
Recombinant hirudin attenuates pulmonary hypertension and thrombosis in acute pulmonary embolism rat model
Wei X et al. · PeerJ
Added to ASH registry: 2026-05-27
Recombinant hirudin suppresses angiogenesis of diffuselarge B-cell lymphoma through regulation of the PAR-1-VEGF
Zhao J et al. · Chemical biology & drug design
Added to ASH registry: 2026-05-27
Recombinant neorudin and its active metabolite hirudin: the fate of a novel anticoagulant drug
Li Q et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Research progress on the treatment of diabetic nephropathy with leech and its active ingredients
Tian F et al. · Frontiers in endocrinology
Added to ASH registry: 2026-05-27
Safety, tolerability, pharmacodynamics, and pharmacokinetics of recombinant Neorudin, a new anticoagulant drug, in patients undergoing coronary angiography
Liu YB et al. · Clinical pharmacology in drug development
Added to ASH registry: 2026-05-27
Starvation-induced changes in the proteome and transcriptome of the salivary glands of leech (Hirudo nipponia)
Cai M et al. · PLoS One
Added to ASH registry: 2026-05-27
Therapeutic Potentials of Medicinal Leech in Chinese Medicine
Wu S et al. · American Journal of Chinese Medicine
Added to ASH registry: 2026-05-27
Antithrombotic pharmacodynamics and metabolomics study in raw and processed products of Whitmania pigra
Kui H et al. · Heliyon
Added to ASH registry: 2026-05-26
Exploring a Hirudin variant from nonhematophagous leeches: Unraveling full-length sequence, alternative splicing, function, and potential as a novel anticoagulant polypeptide
Yi X et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Leech protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites
Liu X, Liang XQ, Lu TC et al. · World journal of gastroenterology
Added to ASH registry: 2026-05-26
Starvation-induced changes in the proteome and transcriptome of the salivary glands of leech (Hirudo nipponia)
Cai M, Shen H, Xing Y, Wang W, Guan F, Luo Y · PLoS one
Added to ASH registry: 2026-05-26
The High-Affinity Chymotrypsin Inhibitor Eglin C Poorly Inhibits Human Chymotrypsin-Like Protease: Gln192 and Lys218 Are Key Determinants
Németh BZ, Kiss B, Sahin-Tóth M, Magyar C, Pál G · Proteins
Added to ASH registry: 2026-05-26
Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina
Ahmed R, Abilov A, Müller C · Parasitology research
Added to ASH registry: 2026-03-18
Exploration of leech therapy in treating gouty rats and its uric acid lowering mechanism
Chao G et al. · Journal of Ayurveda and integrative medicine
Added to ASH registry: 2026-03-18
Immunomodulatory effects of medicinal leech saliva extract on in vitro activated macrophages
Ayhan H et al. · Immunologic research
Added to ASH registry: 2026-03-18
New anticoagulant protein from medicinal leech
Manuvera V et al. · Biochemical and biophysical research communications
Added to ASH registry: 2026-03-18
PEROXIDATION OF SALIVA LIPIDS IN PATIENTS WITH POSTCOVID SYNDROME DURING HIRUDOTHERAPY
Serikbayeva S et al. · Georgian medical news
Added to ASH registry: 2026-03-18
Transcriptomic profiling and the first spatial expression analysis of candidate genes in the salivary gland of the East Asian medicinal leech, Hirudo nipponia
Kim J et al. · Developmental and comparative immunology
Added to ASH registry: 2026-03-18
Tyrosine phosphorylation of recombinant hirudin increases affinity to thrombin and antithrombotic activity
Volkova A, Semenyuk P · Proteins
Added to ASH registry: 2026-03-18
2023
40 articlesAnticoagulant therapies against sepsis-induced disseminated intravascular coagulation.
Umemura et al. · Acute medicine & surgery
Added to ASH registry: 2026-05-28
Bivalirudin plus a high-dose infusion versus heparin in patients with acute coronary syndrome
Galli et al. · European heart journal. Cardiovascular pharmacotherapy
Added to ASH registry: 2026-05-28
Bivalirudin versus Heparin on Net Adverse Clinical Events, Major Adverse Cardiac and Cerebral Events, and Bleeding in Elderly Chinese Patients Treated with Percutaneous Coronary Intervention
Li et al. · The Tohoku journal of experimental medicine
Added to ASH registry: 2026-05-28
Bivalirudin vs heparin in cardiac-cerebral ischemic and bleeding events among Chinese STEMI patients during percutaneous coronary intervention: a retrospective cohort study
Bai et al. · Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Added to ASH registry: 2026-05-28
Bivalirudin-hydrogel coatings of polyvinyl chloride on extracorporeal membrane oxygenation for anticoagulation.
Gao W et al. · Frontiers in cardiovascular medicine
Added to ASH registry: 2026-05-28
Cryo-EM structure of coagulation factor V short.
Mohammed et al. · Blood
Added to ASH registry: 2026-05-28
Effectiveness and Safety of Dabigatran Reversal with Idarucizumab in the Taiwanese Population: A Comparison Based on Eligibility for Inclusion in Clinical Trials.
Dai et al. · Medicina (Kaunas, Lithuania)
Added to ASH registry: 2026-05-28
Evidence-based Management of Major Bleeding in Patients Receiving Direct Oral Anticoagulants: An Updated Narrative Review on the Role of Specific Reversal Agents.
Al Aseri Z et al. · Journal of cardiovascular pharmacology and therapeutics
Added to ASH registry: 2026-05-28
Impact of bivalirudin with a post-procedure infusion versus heparin-monotherapy on stent thrombosis and cardiovascular mortality
Shah · Coronary artery disease
Added to ASH registry: 2026-05-28
In Silico and In Vitro Evaluation of Some Amidine Derivatives as Hit Compounds towards Development of Inhibitors against Coronavirus Diseases.
Hassan AHE et al. · Viruses
Added to ASH registry: 2026-05-28
One case of recurrent ST-segment elevation myocardial infarction in a patient with antiphospholipid syndrome complicated with severe thrombocytopenia within a short period of time: A case report.
Qiu Z et al. · Medicine
Added to ASH registry: 2026-05-28
Outcome after intracranial hemorrhage under dabigatran and reversal with idarucizumab versus under vitamin-K-antagonists - the RIC-ICH study.
Kuklik et al. · Frontiers in neurology
Added to ASH registry: 2026-05-28
Platelet function in neonates and children.
Van Den Helm et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Prevalence, Risk Factors and Control Practices of Livestock Hirudiniasis in Mirab Abaya District, Southern Ethiopia
Seyoum et al. · Veterinary medicine (Auckland, N.Z.)
Added to ASH registry: 2026-05-28
Reversing dabigatran effect with idarucizumab to enable intravenous thrombolysis in patients with acute ischaemic stroke - a single centre experience.
Włodarczyk E et al. · Neurologia i neurochirurgia polska
Added to ASH registry: 2026-05-28
The Complete Mitochondrial Genome of(Annelida: Hirudinea: Glossiphoniidae).
Zhu X et al. · Genes
Added to ASH registry: 2026-05-28
Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation
Chen YT et al. · ACS applied materials & interfaces
Added to ASH registry: 2026-05-27
Bivalirudin in acute coronary syndromes
Galli M et al. · Expert review of cardiovascular therapy
Added to ASH registry: 2026-05-27
Characterization of the natural peptidome of four leeches by integrated proteogenomics and pseudotargeted peptidomics
Liu X et al. · Analytical and bioanalytical chemistry
Added to ASH registry: 2026-05-27
Cloning, characterization, and heterologous expression of a candidate hirudin gene from the salivary gland transcriptome of Hirudo nipponia
Shi P et al. · Scientific reports
Added to ASH registry: 2026-05-27
Ecarin-based methods for measuring thrombin inhibitors
Gosselin RC · Methods in molecular biology
Added to ASH registry: 2026-05-27
Exploiting Chemical Protein Synthesis to Study the Role of Tyrosine Sulfation on Anticoagulants from Hematophagous Organisms
Maxwell JWC et al. · Accounts of chemical research
Added to ASH registry: 2026-05-27
First description study on molecular characterization of Hemiclepsis khankiana (Hirudinea: Glossiphoniidae) in China
He Y et al. · BMC Vet Res
Added to ASH registry: 2026-05-27
From haemadin to haemanorm: Synthesis and characterization of full-length haemadin from the leech Haemadipsa sylvestris and of a novel bivalent, highly potent thrombin inhibitor (haemanorm)
Acquasaliente L et al. · Protein science
Added to ASH registry: 2026-05-27
Functional expression of a thrombin exosite I inhibitor triabin in Escherichia coli
Mo Z et al. · Biochimie
Added to ASH registry: 2026-05-27
Hirudin ameliorates myocardial ischemia-reperfusion injury in a rat model of hemorrhagic shock and resuscitation: roles of NLRP3-signaling pathway
Bai Y et al. · Molecular and cellular biochemistry
Added to ASH registry: 2026-05-27
Identification and Characterization of RK22, a Novel Antimicrobial Peptide from Hirudinaria manillensis against Methicillin Resistant Staphylococcus aureus
Lu X et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Impact of coronary artery disease on clinical outcomes after TAVR: Insights from the BRAVO-3 randomized trial
Feldman D et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
Isolation and characterization of poeciguamerin, a peptide with dual analgesic and antithrombotic activity from leech salivary glands
Wang et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Molecular cloning and functional analysis of HnSaratin from Hirudo nipponia
Cheng B et al. · Gene
Added to ASH registry: 2026-05-27
Molecular mechanisms underlying hematophagia revealed by comparative analyses of leech genomes
Zheng J et al. · GigaScience
Added to ASH registry: 2026-05-27
Possible detection of physiological state disorders with the help of medicinal leeches Hirudo verbana
Aminov R · Annals of parasitology
Added to ASH registry: 2026-05-27
Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations
Hoynoski J et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-27
Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
Gong L et al. · Renal failure
Added to ASH registry: 2026-05-27
Transcriptomic profiling and the first spatial expression analysis of candidate genes in the salivary gland of the East Asian medicinal leech, Hirudo nipponia
Kim JH et al. · Developmental and comparative immunology
Added to ASH registry: 2026-05-27
Yeast surface display of leech hyaluronidase for the industrial production of hyaluronic acid oligosaccharides
Liao L et al. · Eng Microbiol
Added to ASH registry: 2026-05-27
Characterization and antioxidant activities of glycosaminoglycans from dried leech
Shen T et al. · Glycoconjugate journal
Added to ASH registry: 2026-05-26
Intracerebral hirudin injection alleviates cognitive impairment and oxidative stress and promotes hippocampal neurogenesis in rats subjected to cerebral ischemia
Xia X et al. · Neuropathology : official journal of the Japanese Society of Neuropathology
Added to ASH registry: 2026-03-18
Keratitis following leech therapy for periocular eczematous dermatitis: a case report
Özkaya D · BMC complementary medicine and therapies
Added to ASH registry: 2026-03-18
Structural insights into thrombolytic activity of destabilase from medicinal leech
Marin E et al. · Scientific reports
Added to ASH registry: 2026-03-18
2022
21 articlesA Genomic Island of Vibrio cholerae Encodes a Three-Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins
Herrera A et al. · Journal of bacteriology
Added to ASH registry: 2026-05-28
Cerebral Venous Sinus Thrombosis in Preterm Infants.
Christensen et al. · Stroke
Added to ASH registry: 2026-05-28
Direct oral anticoagulants (DOACs): From the laboratory point of view.
Margetić S et al. · Acta pharmaceutica (Zagreb, Croatia)
Added to ASH registry: 2026-05-28
Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice.
Maroney et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Thrombin cleaves IL-33 and modulates IL-33-activated allergic lung inflammation.
Huang Y et al. · Allergy
Added to ASH registry: 2026-05-28
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Paulsen RT, Burrell BD · Frontiers in synaptic neuroscience
Added to ASH registry: 2026-05-27
Complement C3b contributes to-induced platelet aggregation in human whole blood
Landsem A et al. · Frontiers in immunology
Added to ASH registry: 2026-05-27
Exploring the mechanism of hirudin in the treatment of diabetic kidney disease using network pharmacology combined with molecular docking
Xinxin P et al. · Journal of traditional Chinese medicine
Added to ASH registry: 2026-05-27
Hirudin alleviates acute ischemic stroke by inhibiting NLRP3 inflammasome-mediated neuroinflammation
Li WQ et al. · International immunopharmacology
Added to ASH registry: 2026-05-27
Hirudin alleviates acute ischemic stroke by inhibiting NLRP3 inflammasome-mediated neuroinflammation: In vivo and in vitro approaches
Li WQ et al. · International Immunopharmacology
Added to ASH registry: 2026-05-27
Hirudin promotes proliferation and osteogenic differentiation of HBMSCs via activation of cGMP/PKG signaling pathway
Cao S et al. · Bioengineered
Added to ASH registry: 2026-05-27
LC-MS/MS method for determination of r-RGD-hirudin in human plasma and its application in pharmacokinetic study
Peng A et al. · Analytical biochemistry
Added to ASH registry: 2026-05-27
Network pharmacology and experimental verification reveal the mechanism of hirudin in suppressing myocardial hypertrophy
Liu M et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Zhang Z et al. · Cellular and molecular life sciences
Added to ASH registry: 2026-05-27
Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra Whitman
Zhang Y et al. · Journal of Ethnopharmacology
Added to ASH registry: 2026-05-27
Tyrosine-O-sulfation is a widespread affinity enhancer among thrombin interactors
Ripoll-Rozada J et al. · Biochemical Society transactions
Added to ASH registry: 2026-05-27
Life without blood: Molecular and functional analysis of hirudins and hirudin-like factors of the Asian non-hematophagous leech Whitmania pigra
Müller C et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-26
Purification and characterization of a novel thermostable anticoagulant protein from medicinal leech Whitmania pigra
Zhang Y et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Shuxuetong injection and its peptides enhance angiogenesis after hindlimb ischemia by activating the MYPT1/LIMK1/Cofilin pathway
Sun W et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis
Lukas P et al. · Parasitology research
Added to ASH registry: 2026-03-18
Serotonin mediates stress-like effects on responses to non-nociceptive stimuli in the medicinal leech Hirudo verbana
Mack D et al. · The Journal of experimental biology
Added to ASH registry: 2026-03-18
Earlier
719 articles (pre-2022)Artificial intelligence based identification of the functional role of hirudin in diabetic erectile dysfunction treatment
Yang et al. · Pharmacological research
Added to ASH registry: 2026-05-28
Batracobdelloides bangkhenensis sp. n. (Hirudinea: Rhynchobdellida), a new leech species parasite on freshwater snails from Thailand
Chiangkul et al. · Parasitology research
Added to ASH registry: 2026-05-28
Description and taxonomic analysis of a tuberculated turtle leech from the Outer Banks, North Carolina, USA, provisionally identified as Placobdella multilineata Moore, 1953 (Hirudinea: Glossiphoniidae)
Sawyer et al. · Zootaxa
Added to ASH registry: 2026-05-28
Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis
Xu et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-28
Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis
Lu et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Is the South African leech Barbronia gwalagwalensis Westergren & Siddall, 2004 (Hirudinida: Erpobdelliformes: Salifidae) a Paleotropical species?
Klass et al. · Zootaxa
Added to ASH registry: 2026-05-28
Retrospective Analysis of the Effectiveness of a Reduced Dose of Idarucizumab in Dabigatran Reversal.
Stone et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Screening of the Promising Direct Thrombin Inhibitors from Haematophagous Organisms. Part I: Recombinant Analogues and Their Antithrombotic Activity In Vitro.
Kostromina MA et al. · Biomedicines
Added to ASH registry: 2026-05-28
Short tail stories: the hirudin-like factors HLF6 and HLF7 of the Asian medicinal leech, Hirudinaria manillensis.
Müller C et al. · Parasitology research
Added to ASH registry: 2026-05-28
Structure-function of anticoagulant TIX-5, the inhibitor of factor Xa-mediated FV activation.
Maag et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia.
Cui et al. · Scientific reports
Added to ASH registry: 2026-05-28
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
Zhao B et al. · British journal of pharmacology
Added to ASH registry: 2026-05-27
A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin
Liu Y et al. · Pharmacology research & perspectives
Added to ASH registry: 2026-05-27
Bivalirudin and sirolimus co-eluting coronary stent: Potential strategy for the prevention of stent thrombosis and restenosis
Sane M et al. · International journal of pharmaceutics
Added to ASH registry: 2026-05-27
Diselenide crosslinks for enhanced and simplified oxidative protein folding
Mousa R et al. · Communications chemistry
Added to ASH registry: 2026-05-27
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Koh CY et al. · Nature Communications
Added to ASH registry: 2026-05-27
Functional morphology of the suckers and teeth of the medicinal leech Hirudo verbana Carena, 1820 (Annelida; Clitellata; Hirudinida): A scanning electron microscope study
Ayhan H et al. · Microsc Res Tech
Added to ASH registry: 2026-05-27
Impact of anemia on short-term outcomes after TAVR: A subgroup analysis from the BRAVO-3 randomized trial
Razuk V et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
Incidence, predictors, and outcomes associated with acute kidney injury in patients undergoing transcatheter aortic valve replacement: from the BRAVO-3 randomized trial
Chandrasekhar J et al. · Clinical research in cardiology : official journal of the German Cardiac Society
Added to ASH registry: 2026-05-27
Microneedle patch-assisted transdermal administration of recombinant hirudin for the treatment of thrombotic diseases
Men Z et al. · International journal of pharmaceutics
Added to ASH registry: 2026-05-27
Nanoencapsulation of leech saliva extract proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in the Breast cancer cell line (MCF-7)
Shakouri A et al. · BioImpacts
Added to ASH registry: 2026-05-27
NMR-based structural characterization of a two-disulfide-bonded analogue of the FXIIIa inhibitor tridegin
Schmitz T et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
Novel cysteine protease inhibitor derived from the leech: recombinant expression, purification, and characterization
Linhares DDC et al. · Toxins
Added to ASH registry: 2026-05-27
Pharmacological activities and mechanisms of hirudin and its derivatives — a review
Junren C et al. · Frontiers in pharmacology
Added to ASH registry: 2026-05-27
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods
Agten SM et al. · Angewandte Chemie
Added to ASH registry: 2026-05-27
Prostaglandin E1 is an efficient molecular tool for forest leech blood sucking
Zheng F et al. · Frontiers in veterinary science
Added to ASH registry: 2026-05-27
Reperfusion After Fibrinolytic Therapy (RAFT): An open-label, multi-centre, randomised controlled trial of bivalirudin versus heparin in rescue percutaneous coronary intervention
Faour A et al. · PloS one
Added to ASH registry: 2026-05-27
Spontaneous Platelet Aggregation in Blood Is Mediated by FcRIIA Stimulation of Bruton's Tyrosine Kinase
Duan R et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
The origin and evolution of antistasin-like proteins in leeches
Iwama RE et al. · Genome biology and evolution
Added to ASH registry: 2026-05-27
A study of the influence of lead pollution on the anticoagulant activity of Whitmania pigra based on pharmacodynamics and metabolomics research
Chen X et al. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Added to ASH registry: 2026-05-26
A systematic review on Zhilong Huoxue Tongyu capsule in treating cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms and clinical outcomes
Liang P et al. · Journal of ethnopharmacology
Added to ASH registry: 2026-05-26
Nanoencapsulation of leech saliva proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in breast cancer
Shakouri A et al. · BioImpacts : BI
Added to ASH registry: 2026-05-26
Effect of hirudin on arterialized venous flap survival in rabbits
Liu J et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Added to ASH registry: 2026-03-18
Leech therapy (Hirudo medicinalis) attenuates testicular damages induced by testicular ischemia/reperfusion in an animal model
Davoodi F et al. · BMC veterinary research
Added to ASH registry: 2026-03-18
Leech therapy in the treatment of a penile haematoma in a stallion
Nowicki A, Jaworska J, Baranski W · Veterinarni medicina
Added to ASH registry: 2026-03-18
Recombinant Destabilase from
Bobrovsky P et al. · Current issues in molecular biology
Added to ASH registry: 2026-03-18
[Antithrombotic Therapy in Patients with Acute Coronary Syndrome and Atrial Fibrillation].
Darius · Deutsche medizinische Wochenschrift (1946)
Added to ASH registry: 2026-05-28
A new species of buffalo leech in the genusWhitman, 1886 (Arhynchobdellida, Hirudinidae) from Thailand.
Jeratthitikul E et al. · ZooKeys
Added to ASH registry: 2026-05-28
Analysis of anticoagulation reversal survey (ARES).
Rowe et al. · Hospital practice (1995)
Added to ASH registry: 2026-05-28
Antiphospholipid Syndrome Committee of the Brazilian Society of Rheumatology position statement on the use of direct oral anticoagulants (DOACs) in antiphospholipid syndrome (APS).
Balbi GGM et al. · Advances in rheumatology (London, England)
Added to ASH registry: 2026-05-28
Argatroban dosing requirements in extracorporeal life support and other critically ill populations.
Dingman et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Clinical Outcomes of Bivalirudin Versus Heparin in Elderly Patients Undergoing Percutaneous Coronary Intervention: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
Meng S et al. · Cardiovascular drugs and therapy
Added to ASH registry: 2026-05-28
Co-administration of Erythromycin and Leech Salivary Extract Alleviates Osteomyelitis in Rats Induced by Methicillin-Resistant Staphylococcus aureus
Gerivani et al. · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Added to ASH registry: 2026-05-28
Dabigatran Level Before Reversal Can Predict Hemostatic Effectiveness of Idarucizumab in a Real-World Setting.
Gendron et al. · Frontiers in medicine
Added to ASH registry: 2026-05-28
Detailed ultrastructure of the Hirudo (Annelida: Hirudinea) salivary gland
Saglam et al. · Micron (Oxford, England : 1993)
Added to ASH registry: 2026-05-28
Hirudiniasis in Cattle in Mpwapwa District, Dodoma Region of Tanzania
Mulilo et al. · Case reports in veterinary medicine
Added to ASH registry: 2026-05-28
Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study.
Yasaka et al. · Cardiology and therapy
Added to ASH registry: 2026-05-28
Impact of posttranslational modifications on atomistic structure of fibrinogen.
Sovová Ž et al. · PloS one
Added to ASH registry: 2026-05-28
New data on species diversity of Annelida (Oligochaeta, Hirudinea) in the Kharbey lakes system, Bolshezemelskaya tundra (Russia)
Baturina et al. · ZooKeys
Added to ASH registry: 2026-05-28
Outcomes of Cardiac Catheterization in Patients With Atrial Fibrillation on Anticoagulation in Contemporary in Practice: An Analysis of the ORBIT II Registry.
Sherwood et al. · Circulation. Cardiovascular interventions
Added to ASH registry: 2026-05-28
Parasitism of Placobdelloides siamensis (Oka, 1917) (Glossiphoniidae: Hirudinea) in Snail-eating Turtles, Malayemys spp., and the effects of host and aquatic environmental factors
Trivalairat et al. · Biodiversity data journal
Added to ASH registry: 2026-05-28
Perioperative management of anticoagulation
Talari G et al. · Hospital practice (1995)
Added to ASH registry: 2026-05-28
Pharmacological activity and NMR solution structure of the leech peptide HSTX-I
McMahon et al. · Biochemical pharmacology
Added to ASH registry: 2026-05-28
Real World Outcomes Associated with Idarucizumab: Population-Based Retrospective Cohort Study.
Singh et al. · American journal of cardiovascular drugs : drugs, devices, and other interventions
Added to ASH registry: 2026-05-28
Real-world experience with reversal of dabigatran by idarucizumab.
Haastrup et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Treatment strategies for patients with atrial fibrillation and anticoagulant-associated intracranial hemorrhage: an overview of the pharmacotherapy.
Rivera-Caravaca et al. · Expert opinion on pharmacotherapy
Added to ASH registry: 2026-05-28
3D Reconstruction of HvRNASET2 Molecule to Understand Its Antibacterial Role
Baranzini N et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-27
A novel thrombin inhibitory peptide discovered from leech using affinity chromatography combined with ultra-high performance liquid chromatography-high resolution mass spectroscopy
Huang Q et al. · J Chromatogr B Analyt Technol Biomed Life Sci
Added to ASH registry: 2026-05-27
Assessment of platelet biology in equine patients with systemic inflammatory response syndrome
Ehrmann C et al. · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Added to ASH registry: 2026-05-27
Combination of quercetin, hirudin and cinnamaldehyde promotes Schwann cell differentiation and myelination against high glucose by inhibiting ERK signaling
Liu D et al. · Chinese journal of integrative medicine
Added to ASH registry: 2026-05-27
Correction to: Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
Babenko VV et al. · BMC genomics
Added to ASH registry: 2026-05-27
Couplet medicines of leech and centipede granules improve erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats
Ma JX et al. · Bioscience reports
Added to ASH registry: 2026-05-27
Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa
Bäuml CA et al. · European journal of medicinal chemistry
Added to ASH registry: 2026-05-27
Draft Genome of the Asian Buffalo Leech
Guan DL et al. · Front Genet
Added to ASH registry: 2026-05-27
Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
Babenko VV et al. · BMC genomics
Added to ASH registry: 2026-05-27
Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
Babenko VV et al. · BMC Genomics
Added to ASH registry: 2026-05-27
Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers
Hardy M et al. · Journal of clinical medicine
Added to ASH registry: 2026-05-27
European Medicinal Leeches - New Roles in Modern Medicine
Lemke S et al. · Biomedicines
Added to ASH registry: 2026-05-27
High-level constitutive expression of leech hyaluronidase with combined strategies in recombinant Pichia pastoris
Huang H et al. · Appl Microbiol Biotechnol
Added to ASH registry: 2026-05-27
Hirudin protects against kidney damage in streptozotocin-induced diabetic nephropathy rats by inhibiting inflammation via P38 MAPK/NF-κB pathway
Han J et al. · Drug design, development and therapy
Added to ASH registry: 2026-05-27
Hirudin reduces nephropathy microangiopathy in STZ-induced diabetes rats by inhibiting endothelial cell migration
Pang X et al. · Life sciences
Added to ASH registry: 2026-05-27
Hirudin reduces the expression of markers of the extracellular matrix in renal tubular epithelial cells in a rat model of diabetic kidney disease
Pang X et al. · Medical science monitor
Added to ASH registry: 2026-05-27
Preparation and Application of Nanosensor in Safeguarding Heparin Supply Chain
Bi Y et al. · SLAS technology
Added to ASH registry: 2026-05-27
Supplemental Fibrinogen Restores Platelet Inhibitor-Induced Reduction in Thrombus Formation without Altering Platelet Function: An In Vitro Study
Brnthaler T et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
The importance of the Heart Team evaluation before transcatheter aortic valve replacement: Results from the BRAVO-3 trial
Camaj A et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
The molecular characterization, expression analysis and antimicrobial activity of theromacin from Asian polychaeta (Perinereis linea)
Joo MS et al. · Developmental and comparative immunology
Added to ASH registry: 2026-05-27
Time to Change Theory; Medical Leech from a Molecular Medicine Perspective: Leech Salivary Proteins Playing a Potential Role in Medicine
Shakouri A et al. · Advanced pharmaceutical bulletin
Added to ASH registry: 2026-05-27
Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches
Babenko VV, Podgorny OV, Manuvera VA et al. · BMC genomics
Added to ASH registry: 2026-05-26
Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models
Cialdai F et al. · International journal of molecular sciences
Added to ASH registry: 2026-05-26
Self-regulated hirudin delivery for anticoagulant therapy
Xu X, Huang X, Zhang Y et al. · Science advances
Added to ASH registry: 2026-05-26
A new species of Branchellion Savigny, 1822 (Hirudinida: Piscicolidae), a marine leech parasitic on the giant electric ray Narcine entemedor Jordan & Starks (Batoidea: Narcinidae) off Oaxaca, Mexico
RuizEscobar et al. · Systematic parasitology
Added to ASH registry: 2026-05-28
Anticoagulant Decapeptide Interacts with Thrombin at the Active Site and Exosite-I.
Liu H et al. · Journal of agricultural and food chemistry
Added to ASH registry: 2026-05-28
Correct spelling of a recently described species of Helobdella (Annelida: Clitellata: Hirudinea)
Saglam et al. · Zootaxa
Added to ASH registry: 2026-05-28
Dabigatran Reversal with Idarucizumab in an Emergency Lumbar Puncture: A Case Report.
Spagnolello et al. · Current drug safety
Added to ASH registry: 2026-05-28
Direct-Thrombin Inhibitor Utilization in Patients With Heparin-Induced Thrombocytopenia and Undergoing Catheter-Directed Thrombolysis: A Summary of Published Case Reports.
Badreldin et al. · The Journal of cardiovascular nursing
Added to ASH registry: 2026-05-28
Ehrlichia species in pond-farmed leeches (Hirudinaria sp.) in Hubei Province, China
Zhou et al. · PloS one
Added to ASH registry: 2026-05-28
Enhanced potency of prasugrel on protease-activated receptors following bivalirudin treatment for PCI as compared to clopidogrel.
Kimmelstiel C et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Evaluating the ontogenetic external morphology of an ectoparasitic Torix tukubana (Hirudinida: Glossiphoniidae), with records of its new host amphibian species
Kambayashi et al. · Parasitology research
Added to ASH registry: 2026-05-28
Idarucizumab for Reversal of Dabigatran in Early/Emergency Surgeries: A Case Series.
Peacock et al. · The Journal of emergency medicine
Added to ASH registry: 2026-05-28
Management of Severe Bleeding in Patients Treated With Oral Anticoagulants: Proceedings Monograph From the Emergency Medicine Cardiac Research and Education Group-International Multidisciplinary Severe Bleeding Consensus Panel October 20, 2018.
Gibler et al. · Critical pathways in cardiology
Added to ASH registry: 2026-05-28
Na-binding modes involved in thrombin's allosteric response as revealed by molecular dynamics simulations, correlation networks and Markov modeling.
Xiao et al. · Physical chemistry chemical physics : PCCP
Added to ASH registry: 2026-05-28
Optimal Antithrombotic Therapy for Patients with STEMI Undergoing PCI at High Risk of Bleeding.
Tu Y et al. · Current atherosclerosis reports
Added to ASH registry: 2026-05-28
Placobdelloides sirikanchanae sp. nov., a new species of glossiphoniid leech and a parasite of turtles from lower southern Thailand (Hirudinea, Rhynchobdellida)
Trivalairat et al. · ZooKeys
Added to ASH registry: 2026-05-28
Tissue factor pathway inhibitor in atherosclerosis.
Yuan et al. · Clinica chimica acta; international journal of clinical chemistry
Added to ASH registry: 2026-05-28
Vampire in the darkness: a new genus and species of land leech exclusively bloodsucking cave-dwelling bats from China (Hirudinda: Arhynchobdellida: Haemadipsidae)
Huang et al. · Zootaxa
Added to ASH registry: 2026-05-28
A novel protease-activated receptor 1 inhibitor from the leech Whitmania pigra
Ren SH et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-27
Effects of 17-E2 on growth and gonad development of overwintering Whitmania pigra
Wang S et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Added to ASH registry: 2026-05-27
Electrophysiology and transcriptomics reveal two photoreceptor classes and complex visual integration in
Stowasser A et al. · J Exp Biol
Added to ASH registry: 2026-05-27
Gene cloning and expression of a partial sequence of Hirudomacin, an antimicrobial protein that is increased in leech (Hirudo nipponica Whitman) after a blood meal
Ding A et al. · Comparative biochemistry and physiology. Part B
Added to ASH registry: 2026-05-27
Genetic variation, pseudocryptic diversity, and phylogeny of Erpobdella (Annelida: Hirudinida: Erpobdelliformes), with emphasis on Canadian species
Anderson K et al. · Mol Phylogenet Evol
Added to ASH registry: 2026-05-27
Hirudin and decorsins of the North American medicinal leech: gene structure reveals homology to hirudins and hirudin-like factors of Eurasian medicinal leeches
Muller C et al. · The Journal of parasitology
Added to ASH registry: 2026-05-27
Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of Hirudo nipponia
Cheng B et al. · PeerJ
Added to ASH registry: 2026-05-27
In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data
Liu Z et al. · Journal of proteomics
Added to ASH registry: 2026-05-27
Novel Strategy of Gene Delivery System Based on Dendrimer Loaded Recombinant Hirudine Plasmid for Thrombus Targeting Therapy
Chen J et al. · Molecular pharmaceutics
Added to ASH registry: 2026-05-27
Phylogenomic Analysis of a Putative Missing Link Sparks Reinterpretation of Leech Evolution
Phillips AJ et al. · Genome biology and evolution
Added to ASH registry: 2026-05-27
Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis
Cheng RM et al. · Zool Res
Added to ASH registry: 2026-05-27
Revacept, a Novel Inhibitor of Platelet Adhesion, in Patients Undergoing Elective PCI-Design and Rationale of the Randomized ISAR-PLASTER Trial
Schpke S et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
Safety, pharmacokinetics and pharmacodynamics of TNHH, a novel targeted neutrophil-inhibitory hirulog hybrid glycoprotein, in healthy volunteers
Gou ZP et al. · CNS drugs
Added to ASH registry: 2026-05-27
Spatiotemporal Expression of Anticoagulation Factorin Freshwater Leeches
Kwak HJ et al. · Int J Mol Sci
Added to ASH registry: 2026-05-27
The MATRIX trial
Meyer TM et al. · Lancet
Added to ASH registry: 2026-05-27
The MATRIX trial
Shah R et al. · Lancet
Added to ASH registry: 2026-05-27
The salivary transcriptome of Limnatis nilotica and orthology determination of major leech anticoagulants
Iwama R et al. · Parasitology
Added to ASH registry: 2026-05-27
Vampire Venom: Vasodilatory Mechanisms of Vampire Bat Blood Feeding
Kakumanu R et al. · Toxins
Added to ASH registry: 2026-05-27
A novel protease-activated receptor 1 inhibitor from the leech Whitmania pigra
Ren SH, Liu ZJ, Cao Y et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-26
Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden Via Sirtuin 1/NF-κB Pathway
Yao XL et al. · The Journal of surgical research
Added to ASH registry: 2026-05-26
In-depth profiles of bioactive large molecules in saliva secretions of leeches determined by combining salivary gland proteome and transcriptome data
Liu Z, Tong X, Su Y et al. · Journal of proteomics
Added to ASH registry: 2026-05-26
Hirudins of the Asian medicinal leech, Hirudinaria manillensis: same same, but different
Lukas P et al. · Parasitology research
Added to ASH registry: 2026-03-18
American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.
Bates et al. · Blood advances
Added to ASH registry: 2026-05-28
Antiplatelet and anticoagulant activities of two phospholipase A2s purified from Cerastes cerastes venom: Structure-function relationship.
Fatah C et al. · Journal of biochemical and molecular toxicology
Added to ASH registry: 2026-05-28
Bivalirudin versus heparin in percutaneous coronary intervention-a systematic review and meta-analysis of randomized trials stratified by adjunctive glycoprotein IIb/IIIa strategy.
Anantha-Narayanan M et al. · Journal of thoracic disease
Added to ASH registry: 2026-05-28
Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction.
Erlinge D et al. · European heart journal. Acute cardiovascular care
Added to ASH registry: 2026-05-28
Chemical Footprinting Reveals Conformational Changes Following Activation of Factor XI
Stroo et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.
Papageorgiou et al. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Added to ASH registry: 2026-05-28
Duplicated FoxA genes in the leech Helobdella: Insights into the evolution of direct development in clitellate annelids.
Kuo et al. · Developmental dynamics : an official publication of the American Association of Anatomists
Added to ASH registry: 2026-05-28
Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule
Bokoch et al. · Biochemistry
Added to ASH registry: 2026-05-28
Idarucizumab: What Should We Know?
Cortese et al. · Current drug targets
Added to ASH registry: 2026-05-28
Intravenous Thrombolysis in Patients with Acute Ischemic Stroke after a Reversal of Dabigatran Anticoagulation with Idarucizumab: A Real-World Clinical Experience.
Šaňák et al. · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Added to ASH registry: 2026-05-28
Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin.
Abdel Aziz et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Plasma contact factors as therapeutic targets.
Tillman et al. · Blood reviews
Added to ASH registry: 2026-05-28
Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis.
Hanjaya-Putra et al. · JCI insight
Added to ASH registry: 2026-05-28
Probing light chain mutation effects on thrombin via molecular dynamics simulations and machine learning.
Xiao et al. · Journal of biomolecular structure & dynamics
Added to ASH registry: 2026-05-28
Recent advances in the discovery and development of factor XI/XIa inhibitors.
Al-Horani RA et al. · Medicinal research reviews
Added to ASH registry: 2026-05-28
Tranexamic acid blocks the thrombin-mediated delay of epidermal permeability barrier recovery induced by the cedar pollen allergen, Cry j1.
Nakanishi S et al. · Scientific reports
Added to ASH registry: 2026-05-28
Analysis of codon usage patterns in Hirudinaria manillensis reveals a preference for GC-ending codons caused by dominant selection constraints
Guan DL et al. · BMC genomics
Added to ASH registry: 2026-05-27
Cloning of Guamerin gene in Whitmania pigra and its spatio-temporal expression analysis after ingestion
Wu MJ et al. · Zhongguo Zhong yao za zhi
Added to ASH registry: 2026-05-27
Combined systems pharmacology and fecal metabonomics to study the biomarkers and therapeutic mechanism of type 2 diabetic nephropathy treated with leech
Chen R et al. · RSC advances
Added to ASH registry: 2026-05-27
Effect of ingestion on antithrombin activity in different tissues of Whitmania pigra
Wu MJ et al. · China journal of Chinese materia medica
Added to ASH registry: 2026-05-27
Effects of Cu enrichment and release on growth internal quality and relative gene expression of Whitmania pigra
Shi GW et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Added to ASH registry: 2026-05-27
Efficacy and safety of bivalirudin for percutaneous coronary intervention in acute coronary syndromes: a meta-analysis of randomized-controlled trials
Nhrenberg TG et al. · Clinical research in cardiology : official journal of the German Cardiac Society
Added to ASH registry: 2026-05-27
Evaluating prodrug characteristics of a novel anticoagulant fusion protein neorudin, a prodrug targeting release of hirudin variant 2-Lys47 at the thrombosis site
Dong X et al. · European journal of pharmaceutical sciences
Added to ASH registry: 2026-05-27
Isolation and characterization of poecistasin, an anti-thrombotic antistasin-type serine protease inhibitor from leech
Tang X et al. · Toxins
Added to ASH registry: 2026-05-27
Marine leech anticoagulant diversity and evolution
Tessler M et al. · The Journal of parasitology
Added to ASH registry: 2026-05-27
Role of isopeptidolysis in the process of thrombolysis
Baskova IP et al. · Thrombosis research
Added to ASH registry: 2026-05-27
The stomatogastric nervous system of the medicinal leech: its anatomy, physiology and associated aminergic neurons
Mesce KA et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-27
Transcriptomic analysis of the salivary gland of medicinal leech Hirudo nipponia
Lu Z, Shi P, You H, Liu Y, Chen S · PLoS one
Added to ASH registry: 2026-05-26
Leeches-Inspired Hydrogel-Elastomer Integration Materials
Feng J et al. · ACS applied materials & interfaces
Added to ASH registry: 2026-03-18
Novel Sodium Channel Inhibitor From Leeches
Wang G et al. · Frontiers in pharmacology
Added to ASH registry: 2026-03-18
Transcriptomic analysis of the salivary gland of medicinal leech Hirudo nipponia
Lu Z et al. · PloS one
Added to ASH registry: 2026-03-18
Andexanet alfa: a recombinant mimetic of human factor Xa for the reversal of anticoagulant therapies.
Escolar G et al. · Drugs of today (Barcelona, Spain : 1998)
Added to ASH registry: 2026-05-28
Antithrombotic therapy for acute coronary syndrome: Past, present and future.
Sibbing et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick,
Iyer JK et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Added to ASH registry: 2026-05-28
Dabigatran reversal with idarucizumab in a patient undergoing heart transplantation: first European report.
Tralhão et al. · Thrombosis journal
Added to ASH registry: 2026-05-28
H,N andC resonance assignments of Ixolaris, a tissue factor pathway inhibitor from the tick salivary gland.
De Paula VS et al. · Biomolecular NMR assignments
Added to ASH registry: 2026-05-28
Helobdella blinni sp. n. (Hirudinida, Glossiphoniidae) a new species inhabiting Montezuma Well, Arizona, USA
BeresicPerrins et al. · ZooKeys
Added to ASH registry: 2026-05-28
In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation
Sajjadi et al. · Research in pharmaceutical sciences
Added to ASH registry: 2026-05-28
New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey.
Iba et al. · BMJ open
Added to ASH registry: 2026-05-28
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis.
López-López et al. · BMJ (Clinical research ed.)
Added to ASH registry: 2026-05-28
Real-World Experience with Idarucizumab to Reverse Anticoagulant Effect in Dabigatran-Treated Patients: Report of 11 Cases from Taiwan.
Tsai et al. · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Added to ASH registry: 2026-05-28
Real-world use of idarucizumab for dabigatran reversal in three cases of serious bleeding.
Gendron et al. · Clinical case reports
Added to ASH registry: 2026-05-28
Recombinant and chemo-/bio-orthogonal synthesis of liposomal thrombomodulin and its antithrombotic activity.
Wang et al. · Journal of bioscience and bioengineering
Added to ASH registry: 2026-05-28
Risk-adapted management of pulmonary embolism.
Barco et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Spatiotemporal expression of a twist homolog in the leech Helobdella austinensis.
Kim et al. · Development genes and evolution
Added to ASH registry: 2026-05-28
A substrate-selective enzyme-catalysis assembly strategy for oligopeptide hydrogel-assisted combinatorial protein delivery
Jiang T et al. · Nano letters
Added to ASH registry: 2026-05-27
Antithrombotic strategies in the catheterization laboratory for patients with acute coronary syndromes undergoing percutaneous coronary interventions: insights from the EmploYEd antithrombotic therapies in patients with acute coronary Syndromes HOspitalized in iTalian cardiac care units Registry
De Luca L et al. · Journal of cardiovascular medicine (Hagerstown, Md.)
Added to ASH registry: 2026-05-27
Assessment of Fibrin Polymerization During Bivalirudin Anticoagulation for Transcatheter Aortic Valve Replacement
Wipfli C et al. · Journal of cardiothoracic and vascular anesthesia
Added to ASH registry: 2026-05-27
Bivalirudin versus heparin in patients undergoing percutaneous transcatheter aortic valve interventions: A systematic review and meta-analysis
Villablanca PA et al. · Journal of interventional cardiology
Added to ASH registry: 2026-05-27
Development, validation, and clinical pharmacokinetic application of UPLC-MS/MS method for hirudin variant in human plasma
Dong X et al. · Journal of chromatography. B
Added to ASH registry: 2026-05-27
Effect of valve design and anticoagulation strategy on 30-day clinical outcomes in transcatheter aortic valve replacement: Results from the BRAVO 3 randomized trial
Linke A et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-27
Management of refractory bleeding post-cardiopulmonary bypass in an acute heparin-induced thrombocytopenia type II renal failure patient who underwent urgent cardiac surgery with bivalirudin (Angiox) anticoagulation
Hassen K et al. · Perfusion
Added to ASH registry: 2026-05-27
Effectiveness of topical gel of medical leech (Hirudo medicinalis) saliva extract on patients with knee osteoarthritis: A randomized clinical trial
Shakouri A, Adljouy N, Balkani S et al. · Complementary therapies in clinical practice
Added to ASH registry: 2026-05-26
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.
Al-Horani RA et al. · PloS one
Added to ASH registry: 2026-05-28
Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.
Verespy S et al. · Scientific reports
Added to ASH registry: 2026-05-28
Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.
Mehta AY et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo
Branco VG et al. · Biochimica et biophysica acta
Added to ASH registry: 2026-05-28
Comparative Mitogenomics of Leeches (Annelida: Clitellata): Genome Conservation and Placobdella-Specific trnD Gene Duplication.
Oceguera-Figueroa A et al. · PloS one
Added to ASH registry: 2026-05-28
Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity.
Sharma et al. · PloS one
Added to ASH registry: 2026-05-28
Destabilase-lysozyme-2 - original recombinant thrombolytic preparation of medicinal leech inhibits horse platelets aggregation
Rotkina et al. · Patologicheskaia fiziologiia i eksperimental'naia terapiia
Added to ASH registry: 2026-05-28
Direct Thrombin Inhibitor Resistance and Possible Mechanisms.
Cardinale M et al. · Hospital pharmacy
Added to ASH registry: 2026-05-28
G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants.
Zavyalova E et al. · Current medicinal chemistry
Added to ASH registry: 2026-05-28
Identification and functional characterization of a novel antistasin/WAP-like serine protease inhibitor from the tropical sea cucumber, Stichopus monotuberculatus
Yan et al. · Fish & shellfish immunology
Added to ASH registry: 2026-05-28
Management Overview: Taking a Patient with Intracranial Hemorrhage Related to Direct Oral Anticoagulants to the Operating Room.
Alturki A et al. · World neurosurgery
Added to ASH registry: 2026-05-28
Managing reversal of direct oral anticoagulants in emergency situations. Anticoagulation Education Task Force White Paper.
Ageno W et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
More than just one: multiplicity of Hirudins and Hirudin-like Factors in the Medicinal Leech, Hirudo medicinalis
Mller et al. · Molecular genetics and genomics : MGG
Added to ASH registry: 2026-05-28
Purification and Characterization of a Novel Kazal-Type Trypsin Inhibitor from the Leech of Hirudinaria manillensis
Lai et al. · Toxins
Added to ASH registry: 2026-05-28
Spotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran.
Sié · Drug design, development and therapy
Added to ASH registry: 2026-05-28
Structural and functional aspects of decorsin and its analog as recognized by integrin αIIbβ3.
Lao X et al. · Journal of molecular modeling
Added to ASH registry: 2026-05-28
Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function
Shabareesh et al. · Chemical biology & drug design
Added to ASH registry: 2026-05-28
Warfarin and Newer Agents: What the Oral Surgeon Needs to Know.
Steed MB et al. · Oral and maxillofacial surgery clinics of North America
Added to ASH registry: 2026-05-28
A novel selective inhibitor to thrombin-induced platelet aggregation purified from the leech Whitmania pigra
Liu X et al. · Biochem Biophys Res Commun
Added to ASH registry: 2026-05-27
Be ready at any time: postprandial synthesis of salivary proteins in salivary gland cells of the haematophagous leech Hirudo verbana
Lemke S et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-27
Characterisation of separated end hyaluronan oligosaccharides from leech hyaluronidase and evaluation of angiogenesis
Lv M et al. · Carbohydr Polym
Added to ASH registry: 2026-05-27
Functional morphology of suction discs and attachment performance of the Mediterranean medicinal leech
Kampowski T et al. · Journal of the Royal Society, Interface
Added to ASH registry: 2026-05-27
Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
Navarro S et al. · Science translational medicine
Added to ASH registry: 2026-05-27
Identification and characterization of a novel neuropeptide (neuropeptide Y-HS) from leech salivary gland of Haemadipsa sylvestris
Liu WH et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-27
Identification and characterization of novel anticoagulant peptide with thrombolytic effect and nutrient oligopeptides from Whitmania pigra
Ren Y et al. · Amino acids
Added to ASH registry: 2026-05-27
Identification and characterization of novel anticoagulant peptide with thrombolytic effect and nutrient oligopeptides with high branched chain amino acid from Whitmania pigra protein
Ren Y et al. · Amino Acids
Added to ASH registry: 2026-05-27
Pharmacological effects and pharmacokinetic properties of a dual-function peptide 5rolGLP-HV
Ni Z et al. · Applied biochemistry and biotechnology
Added to ASH registry: 2026-05-27
Potential mechanism of acute stent thrombosis with bivalirudin following percutaneous coronary intervention in acute coronary syndromes
Laine M et al. · International journal of cardiology
Added to ASH registry: 2026-05-27
Bivalirudin Anticoagulant Therapy With or Without Platelet Glycoprotein IIb/IIIa Inhibitors During Transcatheter Coronary Interventional Procedures: A Meta-Analysis.
Li et al. · Medicine
Added to ASH registry: 2026-05-28
Bleeding Risk, Management and Outcome in Patients Receiving Non-VKA Oral Anticoagulants (NOACs).
Werth S et al. · American journal of cardiovascular drugs : drugs, devices, and other interventions
Added to ASH registry: 2026-05-28
Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets.
Xu W et al. · Journal of molecular graphics & modelling
Added to ASH registry: 2026-05-28
Compensatory plasticity restores locomotion after chronic removal of descending projections.
Harley CM et al. · Journal of neurophysiology
Added to ASH registry: 2026-05-28
Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions.
Kim TK et al. · International journal for parasitology
Added to ASH registry: 2026-05-28
Current management of heparin-induced thrombocytopenia.
Cosmi · Expert review of hematology
Added to ASH registry: 2026-05-28
Factor V Leiden.
Van Cott EM et al. · American journal of hematology
Added to ASH registry: 2026-05-28
Intracranial bleedings in patients on long-term anticoagulant treatment: Benefits from oral thrombin and factor Xa inhibitors in clinical practice.
Łukasik M et al. · Neurologia i neurochirurgia polska
Added to ASH registry: 2026-05-28
Managing target-specific oral anticoagulant associated bleeding including an update on pharmacological reversal agents.
Siegal · Journal of thrombosis and thrombolysis
Added to ASH registry: 2026-05-28
Plasmin regulation through allosteric, sulfated, small molecules.
Al-Horani RA et al. · Molecules (Basel, Switzerland)
Added to ASH registry: 2026-05-28
Selective disruption of heparin and antithrombin-mediated regulation of human factor IX.
Westmark PR et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Tissue Factor Pathway Inhibitor: Multiple Anticoagulant Activities for a Single Protein.
Mast · Arteriosclerosis, thrombosis, and vascular biology
Added to ASH registry: 2026-05-28
Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides
Duffy et al. · Journal of chemical information and modeling
Added to ASH registry: 2026-05-28
A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein — destabilase-lysozyme from medicinal leech
Kurdyumov AS et al. · BMC biochemistry
Added to ASH registry: 2026-05-27
Bivalirudin as compared to unfractionated heparin in patients undergoing percutaneous coronary revascularization: A meta-analysis of 22 randomized trials
Verdoia M et al. · Thrombosis research
Added to ASH registry: 2026-05-27
Comparative transcriptomic analyses of three species of Placobdella confirms a single origin of blood feeding in leeches
Siddall ME et al. · The Journal of parasitology
Added to ASH registry: 2026-05-27
Enhanced production of leech hyaluronidase by optimizing secretion and cultivation in Pichia pastoris
Kang Z et al. · Appl Microbiol Biotechnol
Added to ASH registry: 2026-05-27
Enzymatic production of specifically distributed hyaluronan oligosaccharides
Yuan P et al. · Carbohydr Polym
Added to ASH registry: 2026-05-27
Generation of recombinant destabilase-lysozyme from medicinal leeches in three different expression systems
Manuvera VA et al. · Protein expression and purification
Added to ASH registry: 2026-05-27
Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification
Xin X et al. · Molecular medicine reports
Added to ASH registry: 2026-05-27
One-hour screening of adulterated heparin by simplified peroxide digestion and fast RPIP-LC-MS(2)
Li H et al. · Analytical chemistry
Added to ASH registry: 2026-05-27
Rational design of stable and functional hirudin III mutants with lower antigenicity
Asgari S et al. · Biologicals : journal of the International Association of Biological Standardization
Added to ASH registry: 2026-05-27
Transcripts involved in hemostasis: exploring salivary complexes from Haementeria vizottoi leeches through transcriptomics
Amorim AM et al. · Toxicon
Added to ASH registry: 2026-05-27
Purification and characterization of an anticoagulant oligopeptide from Whitmania pigra Whitman
Zheng X et al. · Pharmacognosy magazine
Added to ASH registry: 2026-05-26
The venomous cocktail of the vampire snail Colubraria reticulata (Mollusca, Gastropoda)
Modica MV et al. · BMC genomics
Added to ASH registry: 2026-05-26
Effects of Carbon Nanotube Environmental Dispersion on an Aquatic Invertebrate, Hirudo medicinalis
Girardello R et al. · PloS one
Added to ASH registry: 2026-03-18
A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.
Sidhu PS et al. · Bioorganic & medicinal chemistry letters
Added to ASH registry: 2026-05-28
Anticoagulation in atrial fibrillation.
Steinberg BA et al. · BMJ (Clinical research ed.)
Added to ASH registry: 2026-05-28
Contemporary anticoagulation therapy in patients undergoing percutaneous intervention.
Bhatty et al. · Expert review of cardiovascular therapy
Added to ASH registry: 2026-05-28
Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides.
Al-Horani RA et al. · Journal of medicinal chemistry
Added to ASH registry: 2026-05-28
Developmental biology of the leech Helobdella.
Weisblat et al. · The International journal of developmental biology
Added to ASH registry: 2026-05-28
Emergency reversal of anticoagulation: novel agents.
Levine M et al. · Current neurology and neuroscience reports
Added to ASH registry: 2026-05-28
Managing bleeding and emergency reversal of newer oral anticoagulants: a review for primary care providers.
Peacock WF · Hospital practice (1995)
Added to ASH registry: 2026-05-28
Monitoring and reversal strategies for new oral anticoagulants.
Vanden Daelen et al. · Expert review of cardiovascular therapy
Added to ASH registry: 2026-05-28
Morphological and genetic variations of the freshwater leech, Hirudinaria spp., in Peninsular Malaysia
Chong et al. · Biochemical genetics
Added to ASH registry: 2026-05-28
Multiple inhibitory kinetics reveal an allosteric interplay among thrombin functional sites.
Zavyalova E et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Polyphenol compounds belonging to flavonoids inhibit activity of coagulation factor X.
Bijak M et al. · International journal of biological macromolecules
Added to ASH registry: 2026-05-28
Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin.
Henry BL et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects.
Mehta AY et al. · Journal of medicinal chemistry
Added to ASH registry: 2026-05-28
Bivalirudin for acute coronary syndromes: premises, promises and doubts
Capodanno D et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
Comprehensive meta-analysis of safety and efficacy of bivalirudin versus heparin with or without routine glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndrome
Navarese EP et al. · JACC. Cardiovascular interventions
Added to ASH registry: 2026-05-27
Design and rationale for the Minimizing Adverse haemorrhagic events by TRansradial access site and systemic Implementation of angioX program
Valgimigli M et al. · American heart journal
Added to ASH registry: 2026-05-27
Direct thrombin inhibitors: patents 2002-2012
Kong Y et al. · Molecular medicine reports
Added to ASH registry: 2026-05-27
Morphological and molecular characterization of a new species of leech (Glossiphoniidae, Hirudinida): Implications for the health of its imperiled amphibian host (Cryptobranchus alleganiensis)
Hopkins WA et al. · ZooKeys
Added to ASH registry: 2026-05-27
MULTInational non-interventional study of patients with ST-segment elevation myocardial infarction treated with PRimary Angioplasty and Concomitant use of upstream antiplatelet therapy with prasugrel or clopidogrel--the European MULTIPRAC Registry
Clemmensen P et al. · European heart journal. Acute cardiovascular care
Added to ASH registry: 2026-05-27
Prognostic value of angiographic lesion complexity in patients with acute coronary syndromes undergoing percutaneous coronary intervention (from the acute catheterization and urgent intervention triage strategy trial)
Goto K et al. · The American journal of cardiology
Added to ASH registry: 2026-05-27
Scientific foundation and possible implications for practice of the Minimizing Adverse Haemorrhagic Events by Transradial Access Site andSystemic Implementation of AngioX (MATRIX) trial
Valgimigli M et al. · Journal of cardiovascular translational research
Added to ASH registry: 2026-05-27
Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity
Huang Y et al. · BMC structural biology
Added to ASH registry: 2026-05-27
Determination of disulfide linkages in antimicrobial peptides of the macin family by combination of top-down and bottom-up proteomics
Hung CW, Jung S, Grötzinger J, Gelhaus C, Leippe M, Tholey A · Journal of proteomics
Added to ASH registry: 2026-05-26
High-yield novel leech hyaluronidase to expedite the preparation of specific hyaluronan oligomers
Jin P et al. · Scientific reports
Added to ASH registry: 2026-03-18
Medicinal leech therapy in pain syndromes: a narrative review
Koeppen D, Aurich M, Rampp T · Wiener medizinische Wochenschrift (1946)
Added to ASH registry: 2026-03-18
Characterization and optimization of lyophilization and storage conditions of Leech saliva extract from the tropical leech Hirudinaria manillensis
Abdualkader et al. · Pakistan journal of pharmaceutical sciences
Added to ASH registry: 2026-05-28
Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition.
Sidhu PS et al. · Journal of medicinal chemistry
Added to ASH registry: 2026-05-28
Erpobdellid leeches (Annelida, Clitellata, Hirudinida) from Tunisia: new records with the description of a new Trocheta species.
Ben Ahmed R et al. · Zootaxa
Added to ASH registry: 2026-05-28
Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein.
Schuijt et al. · Circulation
Added to ASH registry: 2026-05-28
Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.
Roddick LA et al. · BMC biochemistry
Added to ASH registry: 2026-05-28
Heparin induced thrombocytopenia: review.
Dasararaju et al. · Expert review of hematology
Added to ASH registry: 2026-05-28
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors
Winquist et al. · Biochemistry
Added to ASH registry: 2026-05-28
In vivo anti-hyperglycemic activity of saliva extract from the tropical leech Hirudinaria manillensis
Mohammed et al. · Chinese journal of natural medicines
Added to ASH registry: 2026-05-28
Laboratory monitoring of anticoagulant medications: focus on novel oral anticoagulants.
Baruch L · Postgraduate medicine
Added to ASH registry: 2026-05-28
Management of cardiovascular disease in haemophilia.
Cayla et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Neutron and X-ray crystallographic analysis of the human α-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex.
Yamada et al. · Biochimica et biophysica acta
Added to ASH registry: 2026-05-28
Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate
Alvarenga et al. · Arteriosclerosis, thrombosis, and vascular biology
Added to ASH registry: 2026-05-28
Recurring extracorporeal circuit clotting during continuous renal replacement therapy in fungal sepsis: successful treatment with argatroban.
Ferguson et al. · The American journal of the medical sciences
Added to ASH registry: 2026-05-28
The clinical utility of bivalirudin in patients with coronary artery disease.
Garner et al. · Cardiovascular & hematological agents in medicinal chemistry
Added to ASH registry: 2026-05-28
The leech nervous system: a valuable model to study the microglia involvement in regenerative processes.
Le Marrec-Croq F et al. · Clinical & developmental immunology
Added to ASH registry: 2026-05-28
Use of argatroban: experiences in continuous renal replacement therapy in critically ill patients after cardiac surgery.
Klingele et al. · The Journal of thoracic and cardiovascular surgery
Added to ASH registry: 2026-05-28
Clinical Significance of Leech Therapy in Indian Medicine
Kumar S et al. · Journal of evidence-based complementary & alternative medicine
Added to ASH registry: 2026-05-27
Diversity and selective pressures of anticoagulants in three medicinal leeches (Hirudinida: Hirudinidae, Macrobdellidae)
Kvist S et al. · Ecol Evol
Added to ASH registry: 2026-05-27
May salivary gland secretory proteins from hematophagous leeches reach pharmacologically relevant concentrations in the vertebrate host?
Lemke S et al. · PloS one
Added to ASH registry: 2026-05-27
Medicinal leech therapy in pain syndromes: a narrative review
Koeppen D et al. · Wiener Medizinische Wochenschrift
Added to ASH registry: 2026-05-27
The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand
Boyle AJ et al. · BMC biochemistry
Added to ASH registry: 2026-05-27
Proton bridging in the interactions of thrombin with hirudin and its mimics
Kovach IM, Kakalis L, Jordan F, Zhang D · Biochemistry
Added to ASH registry: 2026-05-26
Antiplatelet and antithrombin strategies in acute coronary syndrome: state-of-the-art review.
Showkathali R et al. · Current cardiology reviews
Added to ASH registry: 2026-05-28
Bivalirudin has its own shelf in the cath lab, eventually.
Cortese et al. · International journal of cardiology
Added to ASH registry: 2026-05-28
Molluscan neurons in culture: shedding light on synapse formation and plasticity.
Schmold N et al. · Journal of molecular histology
Added to ASH registry: 2026-05-28
Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.
Al-Horani RA et al. · European journal of medicinal chemistry
Added to ASH registry: 2026-05-28
An optically stabilized fast-switching light emitting diode as a light source for functional neuroimaging
Wagenaar DA · PloS one
Added to ASH registry: 2026-05-27
Biotechnological production of recombinant analogs of hirudin-1 from Hirudo medicinalis
Kostromina MA et al. · Bioorganicheskaia khimiia
Added to ASH registry: 2026-05-27
Disintegrins from hematophagous sources
Assumpcao TC et al. · Toxins (Basel)
Added to ASH registry: 2026-05-27
Disintegrins from hematophagous sources
Assumpcao TCF et al. · Toxins
Added to ASH registry: 2026-05-27
Interactions of oversulfated chondroitin sulfate (OSCS) from different sources with unfractionated heparin
Gray A et al. · Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Added to ASH registry: 2026-05-27
Outcomes of patients with prior coronary artery bypass grafting and acute coronary syndromes: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial
Nikolsky E et al. · JACC. Cardiovascular interventions
Added to ASH registry: 2026-05-27
Prognostic significance of elevated baseline troponin in patients with acute coronary syndromes and chronic kidney disease treated with different antithrombotic regimens: a substudy from the ACUITY trial
Acharji S et al. · Circulation. Cardiovascular interventions
Added to ASH registry: 2026-05-27
Translational success stories: development of direct thrombin inhibitors
Coppens M et al. · Circulation research
Added to ASH registry: 2026-05-27
Macin family of antimicrobial proteins combines antimicrobial and nerve repair activities
Jung S, Sönnichsen FD, Hung CW et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-26
Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention.
Kimmelstiel et al. · Circulation. Cardiovascular interventions
Added to ASH registry: 2026-05-28
Heparin-induced thrombocytopenia.
Shaikh · Journal of emergencies, trauma, and shock
Added to ASH registry: 2026-05-28
Microsurgeon Hirudo medicinalis as a Natural Bioshuttle for Spontaneous Mass Vaccination against Influenza A Virus
Samadi-Shams et al. · BioImpacts : BI
Added to ASH registry: 2026-05-28
Pediatric catheterization laboratory anticoagulation with bivalirudin.
Forbes et al. · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Added to ASH registry: 2026-05-28
Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.
Corral-Rodríguez M& et al. · Blood
Added to ASH registry: 2026-05-28
Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases.
Henry BL et al. · Biochemical and biophysical research communications
Added to ASH registry: 2026-05-28
The practical management of intracerebral hemorrhage associated with oral anticoagulant therapy.
Masotti et al. · International journal of stroke : official journal of the International Stroke Society
Added to ASH registry: 2026-05-28
Tissue factor/TFPI and blood cells.
Osterud · Thrombosis research
Added to ASH registry: 2026-05-28
Bacterial symbiont and salivary peptide evolution in the context of leech phylogeny
Siddall ME et al. · Parasitology
Added to ASH registry: 2026-05-27
Cytokine loaded biopolymers as a novel strategy to study stem cells during wound-healing processes
Grimaldi A et al. · Macromolecular bioscience
Added to ASH registry: 2026-05-27
Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin
Hsieh YS et al. · Chemical communications
Added to ASH registry: 2026-05-27
How serious a problem is bleeding in patients with acute coronary syndromes?
Baber U et al. · Current cardiology reports
Added to ASH registry: 2026-05-27
Identification of heparin samples that contain impurities or contaminants by chemometric pattern recognition analysis of proton NMR spectral data
Zang Q et al. · Analytical and bioanalytical chemistry
Added to ASH registry: 2026-05-27
Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy
Wang H et al. · Blood
Added to ASH registry: 2026-05-27
Lysozyme activity of the salivary gland secretion of the medicinal leech H. verbana, H. medicinalis and H. orientalis
Baskova IP et al. · Biomeditsinskaia khimiia
Added to ASH registry: 2026-05-27
Prognostic value of the SYNTAX score in patients with acute coronary syndromes undergoing percutaneous coronary intervention: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) trial
Palmerini T et al. · Journal of the American College of Cardiology
Added to ASH registry: 2026-05-27
Redesigning allosteric activation in an enzyme
Rana S et al. · Proceedings of the National Academy of Sciences of the United States of America
Added to ASH registry: 2026-05-27
[Medicinal leeches and hirudotherapy]
Gödekmerdan A et al. · Turkiye parazitolojii dergisi
Added to ASH registry: 2026-03-18
Leech therapy- a holistic approach of treatment in unani (greeko-arab) medicine
Lone A et al. · Ancient science of life
Added to ASH registry: 2026-03-18
Small bite, large impact-saliva and salivary molecules in the medicinal leech, Hirudo medicinalis
Hildebrandt J, Lemke S · Die Naturwissenschaften
Added to ASH registry: 2026-03-18
Evolutionary dynamics of the wnt gene family: a lophotrochozoan perspective.
Cho et al. · Molecular biology and evolution
Added to ASH registry: 2026-05-28
The antithrombotic effect of a novel hirudin derivative after reconstruction of carotid artery in rabbits.
Lu WF et al. · Thrombosis research
Added to ASH registry: 2026-05-28
A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity
Watanabe RM et al. · Biochimie
Added to ASH registry: 2026-05-27
Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study
Saugel B et al. · Critical care (London, England)
Added to ASH registry: 2026-05-27
Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates
Valnickova Z et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
Salivary transcriptome of the North American medicinal leech, Macrobdella decora
Min GS et al. · The Journal of parasitology
Added to ASH registry: 2026-05-27
A novel RGD-toxin protein, Lj-RGD3, from the buccal gland secretion of Lampetra japonica impacts diverse biological activities
Wang J et al. · Biochimie
Added to ASH registry: 2026-05-26
The leech: a novel invertebrate model for studying muscle regeneration and diseases
Grimaldi A et al. · Current pharmaceutical design
Added to ASH registry: 2026-05-26
Platelet aggregation inhibitors from hematophagous animals
Francischetti I · Toxicon : official journal of the International Society on Toxinology
Added to ASH registry: 2026-03-18
Anticoagulant activity of a sulfated galactan: serpin-independent effect and specific interaction with factor Xa.
Glauser et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Anticoagulation for continuous renal replacement therapy.
Tolwani et al. · Seminars in dialysis
Added to ASH registry: 2026-05-28
Argatroban for anticoagulation in continuous renal replacement therapy.
Link et al. · Critical care medicine
Added to ASH registry: 2026-05-28
Argatroban for anticoagulation in continuous renal replacement therapy.
Keegan et al. · Critical care medicine
Added to ASH registry: 2026-05-28
Characterization of an i-type lysozyme gene from the sea cucumber Stichopus japonicus, and enzymatic and nonenzymatic antimicrobial activities of its recombinant protein.
Cong L et al. · Journal of bioscience and bioengineering
Added to ASH registry: 2026-05-28
Grandparental stem cells in leech segmentation: differences in CDC42 expression are correlated with an alternating pattern of blast cell fates.
Zhang et al. · Developmental biology
Added to ASH registry: 2026-05-28
Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology.
Levi et al. · British journal of haematology
Added to ASH registry: 2026-05-28
Long range communication between exosites 1 and 2 modulates thrombin function.
Petrera NS et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A.
Gandhi PS et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.
Qureshi et al. · Biochemistry
Added to ASH registry: 2026-05-28
Molecular basis of thrombomodulin activation of slow thrombin.
Adams et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Mutagenesis studies toward understanding allostery in thrombin.
Qureshi et al. · Biochemistry
Added to ASH registry: 2026-05-28
Thrombin allosteric modulation revisited: a molecular dynamics study.
de Amorim et al. · Journal of molecular modeling
Added to ASH registry: 2026-05-28
A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo
Sheffield WP et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
Clinical experience with argatroban for heparin-induced thrombocytopenia in a large teaching hospital
Bates D et al. · The Canadian journal of hospital pharmacy
Added to ASH registry: 2026-05-27
Extremely low doses of lepirudin in a patient with heparin-induced thrombocytopenia, high bleeding risk and renal insufficiency
Tardy-Poncet B et al. · British journal of haematology
Added to ASH registry: 2026-05-27
Inhibition of coagulation activation and inflammation by a novel Factor Xa inhibitor synthesized from the earthworm Eisenia andrei
Joo SS et al. · Biological & pharmaceutical bulletin
Added to ASH registry: 2026-05-27
Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis
Genzen JR et al. · Transfusion
Added to ASH registry: 2026-05-27
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia
Hursting MJ et al. · Drug safety
Added to ASH registry: 2026-05-27
[Leech hirudo medicinalis: a therapeutic alternative available in Mexico]
Cornejo-Esquerra A et al. · Revista medica del Instituto Mexicano del Seguro Social
Added to ASH registry: 2026-03-18
[Medicinal leeches]
Massart D, Sohawon S, Noordally O · Revue medicale de Bruxelles
Added to ASH registry: 2026-03-18
[New oral anticoagulants: molecular characteristics, mechanisms of action, pharmacokinetics and pharmacodynamics].
Marco P et al. · Medicina clinica
Added to ASH registry: 2026-05-28
Argatroban therapy in patients with hepatic and renal impairment.
Brand et al. · European journal of anaesthesiology
Added to ASH registry: 2026-05-28
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase.
Rudolph V et al. · The Journal of pharmacology and experimental therapeutics
Added to ASH registry: 2026-05-28
Computational study of the putative active form of protein Z (PZa): sequence design and structural modeling.
Chandrasekaran V et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases.
Baetz BE et al. · Pharmacotherapy
Added to ASH registry: 2026-05-28
Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors.
Lancellotti S et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Fragment-based approach to drug lead discovery: overview and advances in various techniques.
Fattori D et al. · Drugs in R&D
Added to ASH registry: 2026-05-28
How Na+ activates thrombin--a review of the functional and structural data.
Huntington · Biological chemistry
Added to ASH registry: 2026-05-28
On designing non-saccharide, allosteric activators of antithrombin.
Raghuraman A et al. · European journal of medicinal chemistry
Added to ASH registry: 2026-05-28
Steroids, histamine and serotonin in medicinal leech salivary gland secretions
Baskova IP et al. · Biomeditsinskaia khimiia
Added to ASH registry: 2026-05-28
Thrombin.
Di Cera E · Molecular aspects of medicine
Added to ASH registry: 2026-05-28
Update on atrial fibrillation: part I.
Savelieva I et al. · Clinical cardiology
Added to ASH registry: 2026-05-28
A novel hirudin derivative characterized with anti-platelet aggregations and thrombin inhibition
Mo W et al. · Journal of thrombosis and thrombolysis
Added to ASH registry: 2026-05-27
A recombinant peptide, hirudin, potentiates the inhibitory effects of stealthy liposomal vinblastine on the growth and metastasis of melanoma
Guo RR et al. · Biological & pharmaceutical bulletin
Added to ASH registry: 2026-05-27
Argatroban anticoagulation in renal dysfunction: a literature analysis
Hursting MJ et al. · Nephron. Clinical practice
Added to ASH registry: 2026-05-27
Decrease of hirudin degradation by deleting the KEX1 gene in recombinant Pichia pastoris
Ni Z et al. · Yeast (Chichester, England)
Added to ASH registry: 2026-05-27
Expression of recombinant Hirudin in transgenic mice milk driven by the goat beta-casein promoter
Yen CH et al. · Biotechnol J
Added to ASH registry: 2026-05-27
Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes
Meng M et al. · Journal of controlled release : official journal of the Controlled Release Society
Added to ASH registry: 2026-05-27
Proteins and peptides of the salivary gland secretion of medicinal leeches Hirudo verbana, H. medicinalis, and H. orientalis
Baskova IP et al. · Biochemistry. Biokhimiia
Added to ASH registry: 2026-05-27
Proteins and peptides of the salivary gland secretion of medicinal leeches Hirudo verbana, H. medicinalis, and H. orientalis
Baskova IP et al. · Biochemistry (Moscow)
Added to ASH registry: 2026-05-27
Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase
Hirbawi J et al. · Biochemistry
Added to ASH registry: 2026-05-27
[Polyfunctionality of destabilase, a lysozyme from a medicinal leech]
Baskova I, Zavalova L · Bioorganicheskaia khimiia
Added to ASH registry: 2026-03-18
[Anticoagulation in continuous renal replacement therapies (CRRT)].
Garcés et al. · Revista da Associacao Medica Brasileira (1992)
Added to ASH registry: 2026-05-28
[Sodium ions as the effector of catalytic action of alpha-thrombin].
Kolodzeĭskaia MV et al. · Ukrains'kyi biokhimichnyi zhurnal (1999 )
Added to ASH registry: 2026-05-28
A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids.
Henry BL et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit.
Davenport · Contributions to nephrology
Added to ASH registry: 2026-05-28
Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics.
Faure G et al. · BMC structural biology
Added to ASH registry: 2026-05-28
Direct antithrombins: mechanisms, trials, and role in contemporary interventional medicine.
Wong CK et al. · American journal of cardiovascular drugs : drugs, devices, and other interventions
Added to ASH registry: 2026-05-28
Effects of unfractionated heparin and glycoprotein IIb/IIIa antagonists versus bivalirdin on myeloperoxidase release from neutrophils.
Li G et al. · Arteriosclerosis, thrombosis, and vascular biology
Added to ASH registry: 2026-05-28
Exosites in the substrate specificity of blood coagulation reactions.
Bock et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Reduced axon sprouting after treatment that diminishes microglia accumulation at lesions in the leech CNS.
Ngu et al. · The Journal of comparative neurology
Added to ASH registry: 2026-05-28
The direct thrombin inhibitor argatroban: a review of its use in patients with and without HIT.
Koster A et al. · Biologics : targets & therapy
Added to ASH registry: 2026-05-28
The haemostatic role of tissue factor pathway inhibitor.
Crawley et al. · Arteriosclerosis, thrombosis, and vascular biology
Added to ASH registry: 2026-05-28
Proteomic analysis methods for characterization of proteins from the salivary gland secretions of the medicinal leech during different seasons
Baskova IP et al. · Biochemistry. Biokhimiia
Added to ASH registry: 2026-05-27
Proteomic analysis methods for characterization of proteins from the salivary gland secretions of the medicinal leech during different seasons
Baskova IP et al. · Biochemistry. Biokhimiia
Added to ASH registry: 2026-05-27
Studies on preparation of recombinant hirudin-2 liposome and its pharmacokinetics by nasal delivery in rats
Zhang YJ et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Added to ASH registry: 2026-05-27
The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen
White TC et al. · FEBS J
Added to ASH registry: 2026-05-27
Thrombin induced tumour growth - pharmacological control
Nowak G et al. · Hamostaseologie
Added to ASH registry: 2026-05-27
A rapid method for isolation and purification of an anticoagulant from Whitmania pigra
Zhong S et al. · Biomedical chromatography : BMC
Added to ASH registry: 2026-05-26
[Research progress in hirudin fusion protein--review]
Zhang C et al. · Zhongguo shi yan xue ye xue za zhi
Added to ASH registry: 2026-03-18
Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis
Siddall M et al. · Proceedings. Biological sciences
Added to ASH registry: 2026-03-18
Hirudin--the long and stony way from an anticoagulant peptide in the saliva of medicinal leech to a recombinant drug and beyond. A historical piece
Nowak G, Schrör K · Thrombosis and haemostasis
Added to ASH registry: 2026-03-18
[Mechanism of thrombosis: physiopathology, role of thrombin and its inhibition by modern therapies].
Hamon M · Archives des maladies du coeur et des vaisseaux
Added to ASH registry: 2026-05-28
Activity-dependent suppression of spontaneous spike generation in the Retzius neurons of the leech Hirudo medicinalis L.
Rose et al. · Invertebrate neuroscience : IN
Added to ASH registry: 2026-05-28
Argatroban: update.
Yeh RW et al. · American heart journal
Added to ASH registry: 2026-05-28
Determinants of specificity of factor xa interaction with its physiological inhibitors.
Rezaie · Mini reviews in medicinal chemistry
Added to ASH registry: 2026-05-28
Economic implications of bivalirudin in the cardiac catheterization laboratory.
Bakhai et al. · Reviews in cardiovascular medicine
Added to ASH registry: 2026-05-28
Ecotin modulates thrombin activity through exosite-2 interactions.
Castro HC et al. · The international journal of biochemistry & cell biology
Added to ASH registry: 2026-05-28
Emerging anticoagulants: mechanism of action and future potential.
Klement P et al. · Vnitrni lekarstvi
Added to ASH registry: 2026-05-28
Maternal expression of a NANOS homolog is required for early development of the leech Helobdella robusta.
Agee et al. · Developmental biology
Added to ASH registry: 2026-05-28
Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin.
Harding SA et al. · Heart (British Cardiac Society)
Added to ASH registry: 2026-05-28
Thrombin-cofactor interactions: structural insights into regulatory mechanisms.
Adams TE et al. · Arteriosclerosis, thrombosis, and vascular biology
Added to ASH registry: 2026-05-28
Tissue factor pathway inhibitor: structure, biology and involvement in disease.
Lwaleed et al. · The Journal of pathology
Added to ASH registry: 2026-05-28
Antibacterial non-glycosidase activity of invertebrate destabilase-lysozyme and of its helical amphipathic peptides
Zavalova LL et al. · Chemotherapy
Added to ASH registry: 2026-05-27
Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction
Levine RL et al. · Chest
Added to ASH registry: 2026-05-27
High-level secretion of dipetarudin, a chimeric thrombin inhibitor, by Pichia pastoris
Lopez M et al. · Protein Expr Purif
Added to ASH registry: 2026-05-27
Investigation of kinetic parameters in vitro of serine proteinases included in the blood coagulation cascade
Danalev DL · Protein and peptide letters
Added to ASH registry: 2026-05-27
Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin
Tardy B et al. · Blood
Added to ASH registry: 2026-05-27
Structural model of an antistasin/notch-like fusion protein from the cocoon wall of the aquatic leech, Theromyzon tessulatum
Mason TA et al. · J Mol Model
Added to ASH registry: 2026-05-27
von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen
Bonnefoy A et al. · J Thromb Haemost
Added to ASH registry: 2026-05-27
Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor.
LaMonte MP et al. · Expert review of cardiovascular therapy
Added to ASH registry: 2026-05-28
Applications of mRNA injections for analyzing cell lineage and asymmetric cell divisions during segmentation in the leech Helobdella robusta.
Zhang et al. · Development (Cambridge, England)
Added to ASH registry: 2026-05-28
Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia.
Tang et al. · The Annals of pharmacotherapy
Added to ASH registry: 2026-05-28
Chemical synthesis of the RGD-protein decorsin: Pro-->Ala replacement reduces protein thermostability.
Frare E et al. · Protein engineering, design & selection : PEDS
Added to ASH registry: 2026-05-28
Determinants of specificity in coagulation proteases.
Page et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Directing thrombin.
Lane DA et al. · Blood
Added to ASH registry: 2026-05-28
Effect of the medicinal leech salivary gland secretion on the state of rat subcutaneous mast cells
Baskova IP et al. · Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Added to ASH registry: 2026-05-28
Fibrinogen and fibrin.
Weisel · Advances in protein chemistry
Added to ASH registry: 2026-05-28
Functional mapping of charged residues of the 82-116 sequence in factor Xa: evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex.
Manithody et al. · Biochemistry
Added to ASH registry: 2026-05-28
Hirudin binding reveals key determinants of thrombin allostery.
Mengwasser KE et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Molecular design and characterization of recombinant long half-life mutants of human tissue factor pathway inhibitor.
Bai H et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Production, purification and characterisation of recombinant Fahsin, a novel antistasin-type proteinase inhibitor
de et al. · FEMS yeast research
Added to ASH registry: 2026-05-28
The Na+ binding channel of human coagulation proteases: novel insights on the structure and allosteric modulation revealed by molecular surface analysis.
Silva et al. · Biophysical chemistry
Added to ASH registry: 2026-05-28
Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy
Reddy BV et al. · The Annals of pharmacotherapy
Added to ASH registry: 2026-05-27
Design, synthesis and structure-activity relationship of a series of fragment analogues of antistasin (ATS) and ghilantens (GLS)
Danalev DL et al. · Bioorganic & medicinal chemistry letters
Added to ASH registry: 2026-05-27
Improvement of the specificity of dipetarudin by site directed mutagenesis
Lpez M et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
Neuropeptide-derived antimicrobial peptides from invertebrates for biomedical applications
Salzet M et al. · Current medicinal chemistry
Added to ASH registry: 2026-05-27
Protein mapping of the salivary complex from a hematophagous leech
Ricci-Silva ME et al. · OMICS
Added to ASH registry: 2026-05-27
Protein mapping of the salivary complex from a hematophagous leech
Ricci-Silva ME et al. · Omics : a journal of integrative biology
Added to ASH registry: 2026-05-27
Thrombin-directed inhibitors: pharmacology and clinical use
White CM · American heart journal
Added to ASH registry: 2026-05-27
By what mechanism do leeches help to salvage ischaemic tissues? A review
Whitaker IS et al. · The British journal of oral & maxillofacial surgery
Added to ASH registry: 2026-05-26
Peptidomimetic thrombin inhibitors
Kikelj D · Pathophysiology of haemostasis and thrombosis
Added to ASH registry: 2026-05-26
Argatroban dosing in intensive care patients with acute renal failure and liver dysfunction.
Williamson et al. · Pharmacotherapy
Added to ASH registry: 2026-05-28
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery.
Carter et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Functional properties of a recombinant chimeric plasminogen activator with platelet-targeted fibrinolytic and anticoagulant potential.
Zhang L et al. · Molecular genetics and metabolism
Added to ASH registry: 2026-05-28
Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side-effects after radiation therapy and as countermeasure against radiation exposure
Wang et al. · Journal of thrombosis and haemostasis : JTH
Added to ASH registry: 2026-05-28
Incorporation of the fluorescent amino acid 7-azatryptophan into the core domain 1-47 of hirudin as a probe of hirudin folding and thrombin recognition
De et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
Molecular dissection of Na+ binding to thrombin.
Pineda et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis.
Francischetti IM et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Purification and identification of recombinant hirudin and its degradation products expressed in Pichia pastoris.
Zhou WB et al. · Preparative biochemistry & biotechnology
Added to ASH registry: 2026-05-28
Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors.
Su Z et al. · Protein engineering, design & selection : PEDS
Added to ASH registry: 2026-05-28
Synthesis and structure-activity relationship of new analogues of antistasin
Danalev et al. · Journal of peptide science : an official publication of the European Peptide Society
Added to ASH registry: 2026-05-28
Antithrombotic effects of saratin on human atherosclerotic plaques
Vilahur G et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
Molecular mapping of the thrombin-heparin cofactor II complex
Fortenberry YM et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
Protein profiling of the medicinal leech salivary gland secretion by proteomic analytical methods
Baskova IP et al. · Biochemistry. Biokhimiia
Added to ASH registry: 2026-05-27
Protein profiling of the medicinal leech salivary gland secretion by proteomic analytical methods
Baskova IP et al. · Biochemistry. Biokhimiia
Added to ASH registry: 2026-05-27
Saratin (an inhibitor of platelet-collagen interaction) decreases platelet aggregation and homocysteine-mediated postcarotid endarterectomy intimal hyperplasia in a dose-dependent manner
Davis JA et al. · Am J Surg
Added to ASH registry: 2026-05-27
The multifunctional role of fibroblasts during wound healing in Hirudo medicinalis
Tettamanti G et al. · Biology of the cell
Added to ASH registry: 2026-05-27
Molecular characterization of two novel antibacterial peptides inducible upon bacterial challenge in an annelid, the leech Theromyzon tessulatum
Tasiemski A, Vandenbulcke F, Mitta G, Lemoine J, Lefebvre C, Sautière PE, Salzet M · The Journal of biological chemistry
Added to ASH registry: 2026-05-26
A distinct patterning mechanism of O and P cell fates in the development of the rostral segments of the leech Helobdella robusta: implications for the evolutionary dissociation of developmental pathway and morphological outcome.
Kuo et al. · Development (Cambridge, England)
Added to ASH registry: 2026-05-28
Activation of AMPA/kainate receptors but not acetylcholine receptors causes Mg2+ influx into Retzius neurones of the leech Hirudo medicinalis.
Muller et al. · The Journal of general physiology
Added to ASH registry: 2026-05-28
Bivalirudin, thrombin and platelets: clinical implications and future directions.
Becker R et al. · The Journal of invasive cardiology
Added to ASH registry: 2026-05-28
Directed evolution towards protease-resistant hirudin variants.
Wirsching F et al. · Molecular genetics and metabolism
Added to ASH registry: 2026-05-28
Engineering of a staphylokinase-based fibrinolytic agent with antithrombotic activity and targeting capability toward thrombin-rich fibrin and plasma clots.
Lian et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.
Berg et al. · Proceedings of the National Academy of Sciences of the United States of America
Added to ASH registry: 2026-05-28
New anticoagulants: current status and future potential
Weitz et al. · American journal of cardiovascular drugs : drugs, devices, and other interventions
Added to ASH registry: 2026-05-28
The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form.
Huntington et al. · Structure (London, England : 1993)
Added to ASH registry: 2026-05-28
Chromacin-like peptide in leeches
Salzet M et al. · Neuro endocrinology letters
Added to ASH registry: 2026-05-27
Coexpression of BiP increased antithrombotic hirudin production in recombinant Saccharomyces cerevisiae
Kim MD et al. · J Biotechnol
Added to ASH registry: 2026-05-27
Direct thrombin inhibitors
Kaplan KL · Expert opinion on pharmacotherapy
Added to ASH registry: 2026-05-27
Effect of plant Kunitz inhibitors from Bauhinia bauhinioides and Bauhinia rufa on pulmonary edema caused by activated neutrophils
Neuhof C et al. · Biological chemistry
Added to ASH registry: 2026-05-27
Optimization of protease-inhibitor interactions by randomizing adventitious contacts
Komiyama T et al. · Proceedings of the National Academy of Sciences
Added to ASH registry: 2026-05-27
The neurite-stimulating activity of components of the salivary gland secretion of the medicinal leech in cultures of sensory neurons
Chalisova NI et al. · Neuroscience and behavioral physiology
Added to ASH registry: 2026-05-27
The neurite-stimulating influence of components of medicinal leech salivary gland secretions in organotypic culture of spinal ganglia
Chalisova NI et al. · Neuroscience and behavioral physiology
Added to ASH registry: 2026-05-27
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Baglin TP et al. · Proceedings of the National Academy of Sciences of the United States of America
Added to ASH registry: 2026-05-28
Historical perspective of the development of thrombin inhibitors
Markwardt et al. · Pathophysiology of haemostasis and thrombosis
Added to ASH registry: 2026-05-28
Micromere lineages in the glossiphoniid leech Helobdella.
Huang et al. · Development (Cambridge, England)
Added to ASH registry: 2026-05-28
Interactions of cytokines and their components in nervous and lymphoid tissue cultures
Penniyainen VA et al. · Doklady biological sciences
Added to ASH registry: 2026-05-27
Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics
Zeiher BG et al. · Critical care medicine
Added to ASH registry: 2026-05-27
Bivalirudin: a direct thrombin inhibitor
Gladwell TD · Clinical therapeutics
Added to ASH registry: 2026-05-26
Bivalirudin: an anticoagulant for acute coronary syndromes and coronary interventions
White HD, Chew DP · Expert opinion on pharmacotherapy
Added to ASH registry: 2026-05-26
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation
De Filippis V, Colombo G, Russo I, Spadari B, Fontana A · Biochemistry
Added to ASH registry: 2026-05-26
Pharmacology of recombinant hirudin
Nowak G · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-03-18
[Decolorization and isolation of recombinant hirudin expressed in the methylotrophic yeast Pichia pastoris].
Zhou WB et al. · Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Added to ASH registry: 2026-05-28
Apparent intracellular Mg2+ buffering in neurons of the leech Hirudo medicinalis.
Günzel et al. · Biophysical journal
Added to ASH registry: 2026-05-28
Argatroban: a direct thrombin inhibitor for heparin-induced thrombocytopenia and other clinical applications.
Chen JL · Heart disease (Hagerstown, Md.)
Added to ASH registry: 2026-05-28
Calcium transients in subcompartments of the leech Retzius neuron as induced by single action potentials.
Beck et al. · Journal of neurobiology
Added to ASH registry: 2026-05-28
Cloning, purification, crystallization and preliminary X-ray diffraction analysis of the antistasin-type inhibitor ghilanten (domain I) from Haementeria ghilianii in complex with porcine beta-trypsin
Rester et al. · Acta crystallographica. Section D, Biological crystallography
Added to ASH registry: 2026-05-28
Comparison of benefits and complications of hirudin versus heparin for patients with acute coronary syndromes undergoing early percutaneous coronary intervention
Roe et al. · The American journal of cardiology
Added to ASH registry: 2026-05-28
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.
Pinto et al. · Journal of medicinal chemistry
Added to ASH registry: 2026-05-28
Dorsal and snail homologs in leech development.
Goldstein et al. · Development genes and evolution
Added to ASH registry: 2026-05-28
Establishment of segment polarity in the ectoderm of the leech Helobdella.
Seaver et al. · Development (Cambridge, England)
Added to ASH registry: 2026-05-28
Management of Heparin-Induced Thrombocytopenia During Renal Replacement Therapy.
Davenport · Hemodialysis international. International Symposium on Home Hemodialysis
Added to ASH registry: 2026-05-28
New anticoagulants.
Hirsh · American heart journal
Added to ASH registry: 2026-05-28
Structure and biology of tissue factor pathway inhibitor.
Bajaj et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
The tissue factor pathway in disseminated intravascular coagulation.
Østerud et al. · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
Tissue factor pathway inhibitor: an update of potential implications in the treatment of cardiovascular disorders.
Kaiser et al. · Expert opinion on investigational drugs
Added to ASH registry: 2026-05-28
Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I
Myles T et al. · Biochemistry
Added to ASH registry: 2026-05-27
Enhanced production of anticoagulant hirudin in recombinant Saccharomyces cerevisiae by chromosomal delta-integration
Kim MD et al. · J Biotechnol
Added to ASH registry: 2026-05-27
Neurite-stimulating activity of secretions from the Hirudo medicinalis salivary gland in cultured sensory neurons
Chalisova NI et al. · Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Added to ASH registry: 2026-05-27
Neurite-stimulating effect of Hirudo medicinalis salivary gland secreting factors in organotypic culture of the dorsal root ganglia
Chalisova NI et al. · Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Added to ASH registry: 2026-05-27
Separation of monomerizing and lysozyme activities of destabilase from medicinal leech salivary gland secretion
Baskova IP et al. · Biochemistry (Mosc)
Added to ASH registry: 2026-05-27
Sequential assignment and secondary structure of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen
Maurer T et al. · J Biomol NMR
Added to ASH registry: 2026-05-27
Technical improvements in genetic manipulation of Pichia pastoris and their application in hirudin expression
Cai CQ et al. · Sheng Wu Gong Cheng Xue Bao
Added to ASH registry: 2026-05-27
The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1
Myles T et al. · European journal of biochemistry
Added to ASH registry: 2026-05-27
The dynamics of stimulating and inhibiting influence on organoid cultures of nervous and lymphoid tissues
Chalisova NI et al. · Doklady biological sciences
Added to ASH registry: 2026-05-27
Bivalirudin: a new approach to anticoagulation
Nawarskas JJ, Anderson JR · Heart disease (Hagerstown, Md.)
Added to ASH registry: 2026-05-26
Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen
Barnes CS, Krafft B, Frech M et al. · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-26
Saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion, decreases platelet aggregation and intimal hyperplasia in a rat carotid endarterectomy model
Cruz CP, Eidt J, Drouilhet J, Brown AT, Wang Y, Barnes CS, Moursi MM · Journal of vascular surgery
Added to ASH registry: 2026-05-26
Proteinase inhibitors from the medicinal leech Hirudo medicinalis
Baskova I, Zavalova L · Biochemistry. Biokhimiia
Added to ASH registry: 2026-03-18
Clinical experience of Argatroban for anticoagulation in cardiovascular surgery.
Ohteki et al. · The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi
Added to ASH registry: 2026-05-28
Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
Slon-Usakiewicz et al. · Biochemistry
Added to ASH registry: 2026-05-28
Heparin-binding exosite of factor Xa.
Rezaie · Trends in cardiovascular medicine
Added to ASH registry: 2026-05-28
Hirudin therapy during thrombolysis for venous thrombosis in heparin-induced thrombocytopenia
Reilly et al. · Vascular medicine (London, England)
Added to ASH registry: 2026-05-28
Re-exposure to recombinant (r)-hirudin in antihirudin antibody-positive patients with a history of heparin-induced thrombocytopenia
Harenberg et al. · British journal of haematology
Added to ASH registry: 2026-05-28
Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis
Lu WY et al. · Biochemistry
Added to ASH registry: 2026-05-27
Destabilase from the medicinal leech is a representative of a novel family of lysozymes
Zavalova LL et al. · Biochimica et biophysica acta
Added to ASH registry: 2026-05-27
Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech
Baskova I et al. · Platelets
Added to ASH registry: 2026-05-27
Lepirudin dosing in dialysis-dependent renal failure
Wittkowsky AK et al. · Pharmacotherapy
Added to ASH registry: 2026-05-27
Modulation of clearance of recombinant serum albumin by either glycosylation or truncation
Sheffield WP et al. · Thrombosis research
Added to ASH registry: 2026-05-27
Novel inhibitors of factor X for use in cardiovascular diseases
Spencer FA et al. · Current cardiology reports
Added to ASH registry: 2026-05-27
PAR3 is a cofactor for PAR4 activation by thrombin
Nakanishi-Matsui M et al. · Nature
Added to ASH registry: 2026-05-27
Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin
Shapiro MJ et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin
Marque PE et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
The stabilization and release of hirudin from liposomes or lipid-assemblies coated with hydrophobically modified dextran
Mumper RJ et al. · AAPS PharmSciTech
Added to ASH registry: 2026-05-27
Therostasin, a novel clotting factor Xa inhibitor from the rhynchobdellid leech Theromyzon tessulatum
Chopin V et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
Use of direct thrombin inhibitors in acute coronary syndrome
Nemergut C et al. · Clinical therapeutics
Added to ASH registry: 2026-05-27
Clinical and scientific considerations in leech therapy for the management of acute venous congestion: an updated review
Weinfeld AB et al. · Annals of plastic surgery
Added to ASH registry: 2026-05-26
[Peptides as inhibitors of thrombin coagulation activity and of thrombocyte aggregation].
Pastorova VE et al. · Uspekhi fiziologicheskikh nauk
Added to ASH registry: 2026-05-28
A protein from the salivary glands of the giant Amazon leech with high sequence homology to a nicotinic acetylcholine receptor subunit
Salgueiro et al. · Zeitschrift fur Naturforschung. C, Journal of biosciences
Added to ASH registry: 2026-05-28
Allosteric modulation of BPTI interaction with human alpha- and zeta-thrombin.
De Cristofaro et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Anticoagulation and anticoagulation reversal with cardiac surgery involving cardiopulmonary bypass: an update.
Despotis et al. · Journal of cardiothoracic and vascular anesthesia
Added to ASH registry: 2026-05-28
Antithrombin agents as anticoagulants and antithrombotics: implications in drug development
Fareed et al. · Seminars in hematology
Added to ASH registry: 2026-05-28
Dipetalogastin, a potent thrombin inhibitor from the blood-sucking insect. Dipetalogaster maximus cDNA cloning, expression and characterization
Mende et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban
Komatsu et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
The stimulating effect of destabilase, a component of Hirudo medicinalis salivary gland secretion, on sensory neuron neurite growth in organotypic culture
Chalisova NI et al. · Tsitologiia
Added to ASH registry: 2026-05-28
Tissue factor pathway inhibitor.
Camici et al. · Minerva medica
Added to ASH registry: 2026-05-28
A new factor Xa inhibitor (lefaxin) from the Haementeria depressa leech
Faria F et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
Biochemical characterization of a thrombin inhibitor from the bloodsucking bug Dipetalogaster maximus
Lange U et al. · Haemostasis
Added to ASH registry: 2026-05-27
Enhancement of heparin cofactor II anticoagulant activity
Bauman SJ et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-27
Evidence that heparin but not hirudin reduces PAI-1 expression in cultured human endothelial cells
Orbe J et al. · Thrombosis research
Added to ASH registry: 2026-05-27
From natural to synthetic multisite thrombin inhibitors
Lombardi A et al. · Biopolymers
Added to ASH registry: 2026-05-27
Functional phage display of leech-derived tryptase inhibitor (LDTI): construction of a library and selection of thrombin inhibitors
Tanaka AS et al. · FEBS letters
Added to ASH registry: 2026-05-27
Future prospects of prophylaxis for deep vein thrombosis
Pini M · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-27
Hyaluronidase activity in leeches (Hirudinea)
Hovingh P et al. · Comp Biochem Physiol B Biochem Mol Biol
Added to ASH registry: 2026-05-27
Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor
De Filippis V et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-27
Invertebrate compounds acting on the hemostatic mechanism
Arocha-Pinango CL et al. · Blood Coagul Fibrinolysis
Added to ASH registry: 2026-05-27
Structure of the complex of the antistasin-type inhibitor bdellastasin with trypsin and modelling of the bdellastasin-microplasmin system
Rester U et al. · Journal of molecular biology
Added to ASH registry: 2026-05-27
The collagen-binding leech products rLAPP and calin prevent both von Willebrand factor and alpha2beta1(GPIa/IIa)-I-domain binding to collagen in a different manner
Depraetere H et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop
Dekker RJ et al. · Journal of molecular biology
Added to ASH registry: 2026-05-27
Anticoagulants in acute coronary syndromes
Turpie AG · The American journal of cardiology
Added to ASH registry: 2026-05-26
Destabilase complexes - natural liposome produced by medicinal leeches Hirudo medicinalis
Nikonov GI, Titova EA · Fundamental & clinical pharmacology
Added to ASH registry: 2026-05-26
An isopeptide bond splitting enzyme from Hirudo medicinalis similar to gamma-glutamyl transpeptidase
Friedrich et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Antithrombin agents as anticoagulants and antithrombotics. Implications in drug development
Fareed et al. · The Medical clinics of North America
Added to ASH registry: 2026-05-28
Binding of hirudin to meizothrombin
Fischer BE et al. · Protein engineering
Added to ASH registry: 2026-05-28
Coagulation factor Xa: the prothrombinase complex as an emerging therapeutic target for small molecule inhibitors.
Scarborough · Journal of enzyme inhibition
Added to ASH registry: 2026-05-28
Dissolution of mural thrombus by specific thrombin inhibition with r-hirudin: comparison with heparin and aspirin
Meyer et al. · Circulation
Added to ASH registry: 2026-05-28
Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis
Riesbeck et al. · Circulation
Added to ASH registry: 2026-05-28
Hirudin (desirudin) and Hirulog (bivalirudin) in acute ischaemic syndromes and the rationale for the Hirulog/Early Reperfusion Occlusion (HERO-2) Study
White et al. · Australian and New Zealand journal of medicine
Added to ASH registry: 2026-05-28
Multiple binding mode of reversible synthetic thrombin inhibitors. A comparative structural analysis
Pavone et al. · Biological chemistry
Added to ASH registry: 2026-05-28
Recombinant hirudin compared with low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement
Robb et al. · The New England journal of medicine
Added to ASH registry: 2026-05-28
Amino acid sequence of piguamerin, an antistasin-type protease inhibitor from the blood sucking leech Hirudo nipponia
Kim DR et al. · Eur J Biochem
Added to ASH registry: 2026-05-27
Amino-acid-sequence determination and biological activity of tessulin, a naturally occurring trypsin-chymotrypsin inhibitor isolated from the leech Theromyzon tessulatum
Chopin V et al. · European journal of biochemistry
Added to ASH registry: 2026-05-27
Bdellastasin, a serine protease inhibitor of the antistasin family from the medical leech
Moser M et al. · European journal of biochemistry
Added to ASH registry: 2026-05-27
Cardiovascular chemotherapy: anticoagulants
Shafer JA · Current opinion in chemical biology
Added to ASH registry: 2026-05-27
Chemical synthesis and structural characterization of the RGD-protein decorsin: a potent inhibitor of platelet aggregation
Polverino de Laureto P et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-27
Heparin accelerates the inhibition of cathepsin G by mucus proteinase inhibitor: potent effect of O-butyrylated heparin
Ermolieff J et al. · The Biochemical journal
Added to ASH registry: 2026-05-27
Fibrino(geno)lytic properties of purified hementerin, a metalloproteinase from the leech Haementeria depressa
Chudzinski-Tavassi AM et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-26
A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent.
Kelley et al. · Blood
Added to ASH registry: 2026-05-28
A strong thrombin-inhibitory prourokinase derivative with sequence elements from hirudin and the human thrombin receptor
Wnendt et al. · Protein engineering
Added to ASH registry: 2026-05-28
Critical role of W60d in thrombin allostery.
Guinto et al. · Biophysical chemistry
Added to ASH registry: 2026-05-28
Delayed treatment with desulfato-hirudin prevents fibrin formation in lipopolysaccharide-induced shock
Siebeck et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Functional characterization of recombinant human meizothrombin and Meizothrombin(desF1). Thrombomodulin-dependent activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI), platelet aggregation, antithrombin-III inhibition.
Côté et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Heparin-induced thrombocytopenia. Pathogenesis, frequency, avoidance and management.
Warkentin · Drug safety
Added to ASH registry: 2026-05-28
Intraocular injection of recombinant hirudin to prevent experimental postoperative fibrin
Toth et al. · Retina (Philadelphia, Pa.)
Added to ASH registry: 2026-05-28
Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains.
Lai et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Molecular mechanisms of thrombin function.
Di Cera et al. · Cellular and molecular life sciences : CMLS
Added to ASH registry: 2026-05-28
Rational engineering of activity and specificity in a serine protease.
Dang et al. · Nature biotechnology
Added to ASH registry: 2026-05-28
Stable expression and purification of a secreted human recombinant prethrombin-2 and its activation to thrombin.
Russo et al. · Protein expression and purification
Added to ASH registry: 2026-05-28
Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties.
Hall et al. · Cellular and molecular life sciences : CMLS
Added to ASH registry: 2026-05-28
Structure-based design of a potent chimeric thrombin inhibitor
Morenweiser et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Hyaluronidases in tissue invasion
Csoka TB et al. · Invasion Metastasis
Added to ASH registry: 2026-05-27
Tridegin, a new peptidic inhibitor of factor XIIIa, from the blood-sucking leech Haementeria ghilianii
Finney S et al. · The Biochemical journal
Added to ASH registry: 2026-05-27
Effects of hirudin (thrombin specific inhibitor) in zebrafish embryos: a developmental role for thrombin
Jagadeeswaran P, Liu YC, Eddy CA · Blood cells, molecules & diseases
Added to ASH registry: 2026-05-26
A recombinant hirudin (IK-HIR02) in healthy volunteers. I. Effects on coagulation parameters and bleeding time
Schenk et al. · Haemostasis
Added to ASH registry: 2026-05-28
A recombinant hirudin (IK-HIR02) in healthy volunteers. II. Effects on platelet adhesion and platelet-induced thrombin generation time
Schenk et al. · Haemostasis
Added to ASH registry: 2026-05-28
Acute urticaria caused by subcutaneous recombinant hirudin: evidence for an IgG-mediated hypersensitivity reaction
Bircher et al. · The Journal of allergy and clinical immunology
Added to ASH registry: 2026-05-28
An increase in activity of serotonergic Retzius neurones may not be necessary for the consummatory phase of feeding in the leech Hirudo medicinalis.
Wilson et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-28
Comparison of desulfatohirudin (REVASC) and heparin as adjuncts to thrombolytic therapy with reteplase in a canine model of coronary thrombosis
Martin et al. · British journal of pharmacology
Added to ASH registry: 2026-05-28
Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin
Féthière et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
DDAVP reduces bleeding during continued hirudin administration in the rabbit
Bove CM et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Distinct effects of recombinant desulfatohirudin (Revasc) and heparin on plasma levels of fibrinopeptide A and prothrombin fragment F1.2 in unstable angina. A multicenter trial
Rao et al. · Circulation
Added to ASH registry: 2026-05-28
Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits
Ragosta et al. · Circulation
Added to ASH registry: 2026-05-28
Hirudins: from leeches to man
Wallis · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
Immobilized hirudin and hirudin-based peptides used for the purification of recombinant human thrombin prepared from recombinant human prothrombin
Fischer et al. · Protein expression and purification
Added to ASH registry: 2026-05-28
Qualitative and quantitative detection of human and recombinant thrombin by binding to leech and recombinant hirudin immobilized at the solid phase
Fischer et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Salivary lipid profiles of the leech (Hirudo medicinalis).
Rabinowitz · Lipids
Added to ASH registry: 2026-05-28
Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis.
Günzel et al. · The Journal of physiology
Added to ASH registry: 2026-05-28
Synthesis of peptide p-nitroanilides mimicking fibrinogen- and hirudin-binding to thrombin. Design of slow reacting thrombin substrates
Rijkers et al. · International journal of peptide and protein research
Added to ASH registry: 2026-05-28
The role of the insertion loop around tryptophan 148 in tthe activity of thrombin.
DiBella et al. · Biochemistry
Added to ASH registry: 2026-05-28
Thrombin inhibitors of bloodsucking animals
Dodt et al. · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
A cysteine-rich serine protease inhibitor (Guamerin II) from the non-blood sucking leech Whitmania edentula
Kim DR et al. · Journal of enzyme inhibition
Added to ASH registry: 2026-05-27
Enhancement of recombinant tissue-type plasminogen activator thrombolysis with a selective factor Xa inhibitor derived from the leech Hirudo medicinalis: comparison with heparin and hirudin in a rabbit thrombosis model
Kornowski R et al. · Coronary artery disease
Added to ASH registry: 2026-05-27
Is colour Doppler ultrasound a sensitive screening method in diagnosing deep vein thrombosis after hip surgery?
Magnusson M et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
Central and peripheral 5-HT receptors in the leech (Hirudo medicinalis) redefined.
Leake et al. · General pharmacology
Added to ASH registry: 2026-05-28
Conversion of thrombin into an anticoagulant by protein engineering.
Gibbs et al. · Nature
Added to ASH registry: 2026-05-28
Core domain of hirudin from the leech Hirudinaria manillensis: chemical synthesis, purification, and characterization of a Trp3 analog of fragment 1-47.
De Filippis V et al. · Biochemistry
Added to ASH registry: 2026-05-28
Development of a novel recombinant serpin with potential antithrombotic properties.
Hopkins et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
High-level secretion of hirudin by Hansenula polymorpha--authentic processing of three different preprohirudins.
Weydemann U et al. · Applied microbiology and biotechnology
Added to ASH registry: 2026-05-28
Hirudin: initial results in acute myocardial infarction, unstable angina and angioplasty
Cannon et al. · Journal of the American College of Cardiology
Added to ASH registry: 2026-05-28
HIT, HITT, and desulfatohirudin: look before you leap
Edmunds et al. · The Journal of thoracic and cardiovascular surgery
Added to ASH registry: 2026-05-28
In situ hybridization reveals transient laminin B-chain expression by individual glial and muscle cells in embryonic leech central nervous system.
Luebke et al. · Journal of neurobiology
Added to ASH registry: 2026-05-28
Influence of piroxicam coadministration on pharmacodynamic parameters and the plasma concentration/effect relationship of recombinant hirudin (CGP 39393)
Thrmann et al. · European journal of clinical pharmacology
Added to ASH registry: 2026-05-28
Ingestive sensory inputs excite serotonin effector neurones and promote serotonin depletion from the leech central nervous system and periphery.
Groome et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-28
Preparation and characterization of anhydrothrombin
Ashton et al. · Biochemistry
Added to ASH registry: 2026-05-28
The Na+ binding site of thrombin.
Di Cera et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
A comparison of the effect of decorsin and two disintegrins, albolabrin and eristostatin, on platelet function
McLane MA et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-27
Calin from Hirudo medicinalis, an inhibitor of platelet adhesion to collagen, prevents platelet-rich thrombosis in hamsters
Deckmyn H et al. · Blood
Added to ASH registry: 2026-05-27
Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor binding to collagen under static and flow conditions
Harsfalvi J et al. · Blood
Added to ASH registry: 2026-05-27
Antithrombotic effect of piyavit, a substance from the medicinal leech (Hirudo medicinalis), containing prostanoid and destabilase fractions
Baskova IP, Zavalova LL, Basanova AV, Aquejouf OM, Azougagh-Oualane F, Doutremepuich C · Biokhimiia
Added to ASH registry: 2026-05-26
Arterial antithrombotic effect of piyavit, the novel pharmacological preparation from the medicinal leech, and of its components, prostanoids and enzyme destabilase
Baskova IP, Aguejouf OM, Azougagh-Oualane F, Zavalova LL, Basanova AV, Doutremepuich C · Thrombosis research
Added to ASH registry: 2026-05-26
Additive effect of the combined administration of low molecular weight heparin and recombinant hirudin on thrombus growth in a rabbit jugular vein thrombosis model
Biemond et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
C-terminal proteolytic degradation of recombinant desulfato-hirudin and its mutants in the yeast Saccharomyces cerevisiae
Heim et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Fibrinolytic compromise by simultaneous administration of site-directed inhibitors of thrombin
Callas et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Hirudins--new antithrombotic agent
Katira et al. · The Journal of the Association of Physicians of India
Added to ASH registry: 2026-05-28
Intracellular pH of giant salivary gland cells of the leech Haementeria ghilianii: regulation and effects on secretion
Wuttke et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-28
Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis
Le et al. · Biochemistry
Added to ASH registry: 2026-05-28
Probing the structure of hirudin from Hirudinaria manillensis by limited proteolysis. Isolation, characterization and thrombin-inhibitory properties of N-terminal fragments.
Vindigni A et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Recombinant desulfatohirudin as a substitute for heparin during cardiopulmonary bypass
Bernabei et al. · The Journal of thoracic and cardiovascular surgery
Added to ASH registry: 2026-05-28
Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trial
Topol et al. · Circulation
Added to ASH registry: 2026-05-28
Synthesis and characterization of a recombinant hirudin-albumin complex
Phaneuf et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Vijayalakshmi et al. · Protein science : a publication of the Protein Society
Added to ASH registry: 2026-05-28
Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers. The European Hirudin in Thrombosis Group (HIT Group)
Close et al. · Coronary artery disease
Added to ASH registry: 2026-05-28
A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis
Sommerhoff CP et al. · Biol Chem Hoppe Seyler
Added to ASH registry: 2026-05-27
Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors
Tsuda Y et al. · Biochemistry
Added to ASH registry: 2026-05-27
Direct thrombin inhibition with Rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement
Eriksson BI et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b
Greagg MA et al. · Biochim Biophys Acta
Added to ASH registry: 2026-05-27
Isolation and characterization of hirustasin, an antistasin-type serine-proteinase inhibitor from the medical leech Hirudo medicinalis
Söllner C et al. · Eur J Biochem
Added to ASH registry: 2026-05-27
Molecular basis for the inhibition of thrombin by hirudin
Stone et al. · Advances in experimental medicine and biology
Added to ASH registry: 2026-05-28
Monomerization of fragment DD by destabilase from the medicinal leech does not alter the N-terminal sequence of the gamma-chain
Zavalova et al. · Thrombosis research
Added to ASH registry: 2026-05-28
Novel hirudin variants from the leech Hirudinaria manillensis. Amino acid sequence, cDNA cloning and genomic organization.
Scacheri E et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Structures of thrombin complexes with a designed and a natural exosite peptide inhibitor.
Qiu X et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Expression, purification and characterization of multigram amounts of a recombinant hybrid HV1-HV2 hirudin variant expressed in Saccharomyces cerevisiae
Lehman ED et al. · Protein expression and purification
Added to ASH registry: 2026-05-27
The complete amino acid sequence of a hirudin variant from the leech Hirudinaria manillensis
Electricwala A et al. · J Protein Chem
Added to ASH registry: 2026-05-27
A potent inhibitor of platelet activating factor from the saliva of the leech Hirudo medicinalis
Orevi et al. · Prostaglandins
Added to ASH registry: 2026-05-28
Anticoagulant efficacy and immunogenicity of the selective factor Xa inhibitor antistasin following subcutaneous administration in the rhesus monkey.
Dunwiddie CT et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Biochemical characterisation of a pancreatic elastase inhibitor from the leech Hirudinaria manillensis
Electricwala et al. · Journal of enzyme inhibition
Added to ASH registry: 2026-05-28
Hirudisins. Hirudin-derived thrombin inhibitors with disintegrin activity
Knapp et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin.
Betz A et al. · Biochemistry
Added to ASH registry: 2026-05-28
Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin.
Le Bonniec et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
pH dependence of the interaction of hirudin with thrombin
Betz et al. · Biochemistry
Added to ASH registry: 2026-05-28
Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis.
Steiner V et al. · Biochemistry
Added to ASH registry: 2026-05-28
Selective factor Xa inhibition by recombinant antistasin prevents vascular graft thrombosis in baboons.
Schaffer LW et al. · Arteriosclerosis and thrombosis : a journal of vascular biology
Added to ASH registry: 2026-05-28
Studies on the anticoagulant properties of hementin
Electricwala. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
Analysis of recombinant proteins by isoelectric focusing in immobilized pH gradients
Bischoff R et al. · Electrophoresis
Added to ASH registry: 2026-05-27
Use of the medicinal leech in the treatment of ear diseases
Seleznev K et al. · ORL; journal for oto-rhino-laryngology and its related specialties
Added to ASH registry: 2026-03-18
[A dimer of fragment D from stabilized fibrin--a substrate for the destabilase enzyme (gamma-glutamyl-epsilon-lysyl-isopeptidase)].
Zavalova LL et al. · Biokhimiia (Moscow, Russia)
Added to ASH registry: 2026-05-28
Development of serotonin-induced ion currents in identified embryonic Retzius cells from the medicinal leech (Hirudo medicinalis).
Lessmann et al. · The Journal of neuroscience : the official journal of the Society for Neuroscience
Added to ASH registry: 2026-05-28
Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets
Jandrot-Perrus et al. · Thrombosis and haemostasis
Added to ASH registry: 2026-05-28
Effects of hementin on fibrinogen mediated platelet aggregation/deaggregation in vitro
Munro et al. · Platelets
Added to ASH registry: 2026-05-28
Hementin Deaggregates Platelets Faster than it Detibrinogenates Platelet-rich Plasma
Munro et al. · Platelets
Added to ASH registry: 2026-05-28
Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.
Boulanger CM et al. · Circulation research
Added to ASH registry: 2026-05-28
Hirudin and platelets.
Glusa E · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
Hirudin: amino-terminal residues play a major role in the interaction with thrombin
Lazar et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Interaction of hirudin with the dysthrombins Quick I and II
Stone et al. · Biochemistry
Added to ASH registry: 2026-05-28
Isolation of thrombin inhibitor from the leech Hirudinaria manillensis.
Electricwala A et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
Structure-function relationships of the C-terminal functional domain of hirudin and its variants.
Krstenansky JL et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.
Liu LW et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Thrombin inhibition by covalently bound hirudin
Ito et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
Thrombin structure and function: why thrombin is the primary target for antithrombotics
Fenton et al. · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-28
Thrombolytics and anti-coagulants from leeches
Sawyer · Bio/technology (Nature Publishing Company)
Added to ASH registry: 2026-05-28
Toxicology of hirudin.
Klöcking HP · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
Calin--a platelet adhesion inhibitor from the saliva of the medicinal leech
Munro R et al. · Blood Coagul Fibrinolysis
Added to ASH registry: 2026-05-27
Different susceptibility of elastase inhibitors to inactivation by proteinases from Staphylococcus aureus and Pseudomonas aeruginosa
Sponer M et al. · Biol Chem Hoppe Seyler
Added to ASH registry: 2026-05-27
Expression and characterization of the N-terminal half of antistasin, an anticoagulant protein derived from the leech Haementeria officinalis
Palladino LO et al. · Protein Expr Purif
Added to ASH registry: 2026-05-27
Purification and characterization of recombinant antistasin: a leech-derived inhibitor of coagulation factor Xa
Nutt EM et al. · Arch Biochem Biophys
Added to ASH registry: 2026-05-27
Studies on the anticoagulant, antimetastatic and heparin-binding properties of ghilanten-related inhibitors
Brankamp RG et al. · Blood Coagul Fibrinolysis
Added to ASH registry: 2026-05-27
Binding of the recombinant proteinase inhibitor eglin c from leech Hirudo medicinalis to serine (pro)enzymes: a comparative thermodynamic study
Ascenzi P, Aducci P, Amiconi G et al. · Journal of molecular recognition
Added to ASH registry: 2026-05-26
Destabilase, the novel epsilon-(gamma-Glu)-Lys isopeptidase with thrombolytic activity
Baskova IP, Nikonov GI · Blood coagulation & fibrinolysis
Added to ASH registry: 2026-05-26
Interaction of hementin with fibrinogen and fibrin
Budzynski AZ · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-26
Structure-activity relationships of recombinant hirudins
Stürzebecher J, Walsmann P · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-26
The biological function of hementin in the proboscis of the leech Haementeria ghilianii
Sawyer RT, Jones CP, Munro R · Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Added to ASH registry: 2026-05-26
The history of leeching and hirudin
Fields W · Haemostasis
Added to ASH registry: 2026-03-18
Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs.
Hoffmann H et al. · The American review of respiratory disease
Added to ASH registry: 2026-05-28
Glutaminergic responses of neuropile glial cells and Retzius neurones in the leech central nervous system.
Dörner et al. · Brain research
Added to ASH registry: 2026-05-28
Isolation and purification of novel hirudins from the leech Hirudinaria manillensis by high-performance liquid chromatography.
Steiner V et al. · Journal of chromatography
Added to ASH registry: 2026-05-28
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans
Ragg et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Preparation of monoclonal antibodies to hirudin and hirudin peptides. A method for studying the hirudin--thrombin interaction.
Schlaeppi JM et al. · European journal of biochemistry
Added to ASH registry: 2026-05-28
Production, properties, and thrombin inhibitory mechanism of hirudin amino-terminal core fragments.
Chang JY · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Purification and characterization of hementin, a fibrinogenolytic protease from the leech Haementeria ghilianii
Swadesh et al. · Journal of chromatography
Added to ASH registry: 2026-05-28
The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.
Naski MC et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Thrombin-bound conformation of the C-terminal fragments of hirudin determined by transferred nuclear Overhauser effects
Ni et al. · Biochemistry
Added to ASH registry: 2026-05-28
A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule
Kirschbaum NE, Budzynski AZ · The Journal of biological chemistry
Added to ASH registry: 2026-05-26
Interference of recombinant eglin C, a proteinase inhibitor extracted from leeches, with neutrophil-mediated platelet activation
Renesto P, Ferrer-Lopez P, Chignard M · Laboratory investigation
Added to ASH registry: 2026-05-26
Antistasin, an inhibitor of coagulation and metastasis, binds to sulfatide (Gal(3-SO4) beta 1-1Cer) and has a sequence homology with other proteins that bind sulfated glycoconjugates.
Holt GD et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Antithrombin activity of a peptide corresponding to residues 54-75 of heparin cofactor II
Hortin et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Biochemistry and genetic engineering of hirudin
Johnson et al. · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-28
Contribution of the N-terminal region of hirudin to its interaction with thrombin.
Wallace A et al. · Biochemistry
Added to ASH registry: 2026-05-28
The emergency management of a medicinal leech bite
Adams SL · Annals of emergency medicine
Added to ASH registry: 2026-05-28
The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex
Chang et al. · The Journal of biological chemistry
Added to ASH registry: 2026-05-28
Antistasin, a leech-derived inhibitor of factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site
Dunwiddie C et al. · J Biol Chem
Added to ASH registry: 2026-05-27
Cloning and expression of cDNA encoding antistasin, a leech-derived protein having anti-coagulant and anti-metastatic properties
Han JH et al. · Gene
Added to ASH registry: 2026-05-27
Isolation of recombinant hirudin by preparative high-performance liquid chromatography
Bischoff R et al. · J Chromatogr
Added to ASH registry: 2026-05-27
Comparison of hirudins
Fink E · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-05-26
Production and evaluation of recombinant hirudin
Courtney M et al. · Seminars in thrombosis and hemostasis
Added to ASH registry: 2026-03-18
[The use of the specific thrombin inhibitor hirudin in diagnostic and biochemical studies].
Walsmann P · Die Pharmazie
Added to ASH registry: 2026-05-28
Design, synthesis and antithrombin activity for conformationally restricted analogs of peptide anticoagulants based on the C-terminal region of the leech peptide, hirudin
Krstenansky et al. · Biochimica et biophysica acta
Added to ASH registry: 2026-05-28
Excitability and secretory activity in the salivary gland cells of jawed leeches (Hirudinea: Gnathobdellida)
Marshall et al. · The Journal of experimental biology
Added to ASH registry: 2026-05-28
Interaction of hirudin with thrombin: identification of a minimal binding domain of hirudin that inhibits clotting activity.
Mao SJ et al. · Biochemistry
Added to ASH registry: 2026-05-28
Segmentation in leech development.
Weisblat et al. · Development (Cambridge, England)
Added to ASH registry: 2026-05-28
Ultrastructure of the anterior salivary gland cells of the giant leech, Haementeria ghilianii (Annelida, Hirudinea)
Walz et al. · Journal of morphology
Added to ASH registry: 2026-05-28
Evidence for the identity of hirudin isolated after kidney passage with the starting material
Henschen A et al. · Folia Haematol Int Mag Klin Morphol Blutforsch
Added to ASH registry: 2026-05-27
The comeback of hirudin--an old-established anticoagulant agent
Markwardt F et al. · Folia Haematol Int Mag Klin Morphol Blutforsch
Added to ASH registry: 2026-05-27
Binding of the recombinant proteinase inhibitor eglin c from leech Hirudo medicinalis to human leukocyte elastase, bovine alpha-chymotrypsin and subtilisin Carlsberg: thermodynamic study
Ascenzi P, Amiconi G, Menegatti E, Guarneri M, Bolognesi M, Schnebli HP · Journal of enzyme inhibition
Added to ASH registry: 2026-05-26
Afferent sensillar inputs to the Retzius cell of the leech Hirudo medicinalis.
Carretta et al. · Archives italiennes de biologie
Added to ASH registry: 2026-05-28
Alpha-thrombin-induced pulmonary vasoconstriction.
Horgan MJ et al. · Journal of applied physiology (Bethesda, Md. : 1985)
Added to ASH registry: 2026-05-28
Axonal projections of the Retzius cells to the dorsal segmental root in the leech Hirudo medicinalis.
Carretta et al. · Archives italiennes de biologie
Added to ASH registry: 2026-05-28
Influence of chain shortening on the inhibitor properties of hirudin and eglin c
Dodt et al. · Biological chemistry Hoppe-Seyler
Added to ASH registry: 2026-05-28
Rapid purification and revised amino-terminal sequence of hirudin: a specific thrombin inhibitor of the bloodsucking leech.
Mao SJ et al. · Analytical biochemistry
Added to ASH registry: 2026-05-28
The regulation of intracellular pH by identified glial cells and neurones in the central nervous system of the leech.
Deitmer et al. · The Journal of physiology
Added to ASH registry: 2026-05-28
The saliva of the medicinal leech Hirudo medicinalis--I. Biochemical characterization of the high molecular weight fraction
Rigbi M et al. · Comparative biochemistry and physiology. B, Comparative biochemistry
Added to ASH registry: 2026-05-28
The saliva of the medicinal leech Hirudo medicinalis--II. Inhibition of platelet aggregation and of leukocyte activity and examination of reputed anaesthetic effects
Rigbi et al. · Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
Added to ASH registry: 2026-05-28
Ozone effects on inhibitors of human neutrophil proteinases
Smith CE et al. · Arch Biochem Biophys
Added to ASH registry: 2026-05-27
Leech Retzius cells and 5-hydroxytryptamine
Leake · Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
Added to ASH registry: 2026-05-28
Refined 1.2 Å crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c
Bode W, Papamokos E, Musil D, Seemueller U, Fritz H · The EMBO journal
Added to ASH registry: 2026-05-26
Synaptic effects elicited in the Retzius cells of the leech Hirudo medicinalis by stimulation of the segmental roots.
Carretta et al. · Archives italiennes de biologie
Added to ASH registry: 2026-05-28
The complete covalent structure of hirudin. Localization of the disulfide bonds
Dodt et al. · Biological chemistry Hoppe-Seyler
Added to ASH registry: 2026-05-28
On the isolation of the thrombin inhibitor hirudin
Walsmann P et al. · Thromb Res
Added to ASH registry: 2026-05-27
Pharmacology of hirudin: one hundred years after the first report of the anticoagulant agent in medicinal leeches
Markwardt F et al. · Biomed Biochim Acta
Added to ASH registry: 2026-05-27
Eglin c, a pharmacologically active elastase inhibitor
Schnebli HP, Seemüller U, Fritz H et al. · European journal of respiratory diseases. Supplement
Added to ASH registry: 2026-05-26
Eglin-c, a polypeptide derived from the medicinal leech, prevents human neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in the hamster
Snider GL, Stone PJ, Lucey EC et al. · The American review of respiratory disease
Added to ASH registry: 2026-05-26
Hementin: anticoagulant protease from the salivary gland of the leech Haementeria ghilianii.
Malinconico SM et al. · The Journal of laboratory and clinical medicine
Added to ASH registry: 2026-05-28
Inhibition of the thrombin-platelet reaction by hirudin.
Hoffmann A et al. · Haemostasis
Added to ASH registry: 2026-05-28
Protein C.
Esmon · Progress in hemostasis and thrombosis
Added to ASH registry: 2026-05-28
Protease inhibitors in Haementeria leech species
Murer EH et al. · Thromb Haemost
Added to ASH registry: 2026-05-27
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli
Rink H, Liersch M, Sieber P, Meyer F · Nucleic acids research
Added to ASH registry: 2026-05-26
The functional domain of hirudin, a thrombin-specific inhibitor.
Chang JY · FEBS letters
Added to ASH registry: 2026-05-28
Cell clones and segmentation in leech development.
Zackson · Cell
Added to ASH registry: 2026-05-28
Immunohistochemical demonstration of peptides, serotonin and dopamine-beta-hydroxylase-like material in the nervous system of the leech Hirudo medicinalis.
Osborne et al. · Histochemistry
Added to ASH registry: 2026-05-28
Two bidirectional nerve cord systems converging with electrical and chemical synapses on the Retzius cells of the leech Hirudo Medicinalis.
Carretta et al. · Archives italiennes de biologie
Added to ASH registry: 2026-05-28
Biochemical and pharmacological aspects of the thrombin inhibitor hirudin
Walsmann P et al. · Pharmazie
Added to ASH registry: 2026-05-27
The amine and amino acid composition in the Retzius cells of the leech Hirudo medicinalis.
Osborne et al. · Experientia
Added to ASH registry: 2026-05-28
Isolation of hirudin from medicinal leech
Markwardt F et al. · Pharmazie
Added to ASH registry: 2026-05-27
Purification and analysis of the thrombin inhibitor hirudin
Markwardt F et al. · Hoppe Seylers Z Physiol Chem
Added to ASH registry: 2026-05-27
The hyaluronidase of the leech: an endoglucuronidase
Linker A et al. · Nature
Added to ASH registry: 2026-05-27