Medicinal leech therapy in pain syndromes: a narrative review
Narrative review published in Wiener Medizinische Wochenschrift (2013)
Abstract
Medicinal leech therapy is used in a variety of conditions; most of which have pain as a major symptom. Its mode of action relies on the injection of leech saliva into patients' tissues during the process of blood withdrawal. Leech saliva contains active ingredients with anti-inflammatory, thrombolytic, anti-coagulant and blood- and lymph-circulation enhancing properties. A specific analgesic substance within the leech saliva is yet to be identified. Pain relief from leech therapy is rapid, effective and long-lasting in many conditions. This review compiles studies and case reports that provide clinical evidence for leech therapy's analgesic effects.
Abstract sourced from PubMed (NCBI) for the cited record. See the original publication for the authoritative version.
Summary
Narrative review on leech therapy's analgesic effect across multiple pain syndromes (osteoarthritis, epicondylitis, hematoma, thrombophlebitis, varicose veins); the saliva contains anti-inflammatory, thrombolytic, anti-coagulant and circulation-enhancing molecules, though a specific analgesic compound has not been identified.
Why This Matters for Hirudotherapy
Synthesizes evidence for the underexplored analgesic action of leech saliva.
Citation
Medicinal leech therapy in pain syndromes: a narrative review.
Koeppen D et al. · Wiener Medizinische Wochenschrift, 2013
Added to ASH library: May 27, 2026 · Site last updated: June 18, 2026